| Light chain deposition disease | |
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MedLine Citation:
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PMID: 7917761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the case of a rather rare form of K-light chain deposition disease (LCDD) in a 61-year-old man with hypertension and rapidly progressing nephropathy. Laboratory findings prompted suspicion of the diagnosis which was confirmed by light-microscopic and immunofluorescent studies of samples taken by percutaneous renal and liver biopsy. Hepatic and urinary K-light chains were present; no circulating light chains were detected. Bone marrow examination evidenced mild infiltration of lymphoid cells, all positive for K-light chain staining. Plasma cells were within normal ranges. LCDD appeared as nodular glomerulosclerosis with rare crescents and extensive tubular involvement with K-light chain deposits. There was no evidence of altered liver function, nor was amyloid found in the bone marrow, kidney or liver. After one year of continuous therapy with melphalan and prednisone, the patient's renal function has not worsened. We conclude with a review of the clinical and physiopathological features of the light chain subgroup of monoclonal immunoglobulin deposition diseases (MIDD). |
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Authors:
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E Terzani; B Alterini; M Doni; V Lampronti; C Lusini; G Fazzini |
Publication Detail:
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Type: Case Reports; English Abstract; Journal Article |
Journal Detail:
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Title: Annali italiani di medicina interna : organo ufficiale della Società italiana di medicina interna Volume: 9 ISSN: 0393-9340 ISO Abbreviation: Ann. Ital. Med. Int. Publication Date: 1994 Apr-Jun |
Date Detail:
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Created Date: 1994-11-07 Completed Date: 1994-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8806705 Medline TA: Ann Ital Med Int Country: ITALY |
Other Details:
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Languages: ita Pagination: 100-4 Citation Subset: IM |
Affiliation:
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Divisione di Medicina Interna IV, Policlinico di Careggi, Firenze. |
Vernacular Title:
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La malattia da deposito di catene leggere. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Glomerulonephritis, Membranoproliferative
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diagnosis,
immunology Humans Hypergammaglobulinemia / diagnosis*, immunology Immunoglobulin kappa-Chains* / analysis Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin kappa-Chains |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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