Document Detail


Light chain deposition disease as a rare cause of restrictive cardiomyopathy.
MedLine Citation:
PMID:  20128164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report an unusual case of a 47-year-old Caucasian woman who presented with severe dyspnoea as a manifestation of restrictive cardiomyopathy, found to be due to myocardial deposition of kappa light chains. Non-routine specific immunofluorescence stainings of endomyocardial biopsy specimens were key for the diagnosis of myocardial light chain deposition disease. We discuss non-amyloidotic cardiac immunoglobulin deposition disease in contrast to cardiac amyloidosis.
Authors:
Pieter Koopman; Jo Van Dorpe; Bart Maes; Karl Dujardin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta cardiologica     Volume:  64     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  821-4     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Heilig Hart Ziekenhuis, Roeselare, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Cardiomyopathy, Restrictive / etiology*
Coloring Agents / diagnostic use
Congo Red / diagnostic use
Dyspnea / etiology*
Endocardium / pathology
Fatal Outcome
Female
Heart Failure / etiology
Humans
Immunoglobulin Light Chains* / metabolism
Immunohistochemistry
Middle Aged
Myocardium / pathology
Paraproteinemias / complications*
Chemical
Reg. No./Substance:
0/Coloring Agents; 0/Immunoglobulin Light Chains; 573-58-0/Congo Red

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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