| Light aversion in mice depends on nonimage-forming irradiance detection. | |
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MedLine Citation:
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PMID: 21038932 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Detection of light in the eye underlies image-forming vision, but also regulates adaptive responses in physiology and behavior. Typically these adaptive responses do not involve image-forming vision, but depend on a relatively absolute measure of brightness (nonimage-forming irradiance detection). The goal of this study was to further understand how image-forming vision and nonimage-forming irradiance detection contribute to the effects of light on behavior. Three light dependent behaviors were assessed in wild-type, Rpe65-/- and rd1 mice. In Rpe65-/- mice, nonimage-forming irradiance detection is severely attenuated, but rod based visual acuity is relatively preserved. In rd1 mice visual acuity is nonrecordable, but nonimage-forming responses are less severely attenuated than Rpe65-/-. Positive masking, an image-forming vision dependent increase in wheel running, was absent in rd1 and restricted to higher irradiances in Rpe65-/-. Negative masking, a suppression of wheel running sensitivity with nonimage-forming irradiance detection input, was increased in rd1, but reduced in Rpe65-/- mice. By contrast, light aversion, an avoidance of brightly lit areas, was abolished in both Rpe65-/- and rd1. This shows that image-forming vision is not sufficient for light aversion, suggesting nonimage-forming irradiance detection motivates this behavior. Further, the differing effects of disease suggest that negative masking and light aversion are distinct responses with specialized nonimage-forming irradiance detection pathways. |
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Authors:
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Stewart Thompson; Ana Recober; Timothy W Vogel; Adisa Kuburas; Jessica A Owens; Val C Sheffield; Andrew F Russo; Edwin M Stone |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Behavioral neuroscience Volume: 124 ISSN: 1939-0084 ISO Abbreviation: Behav. Neurosci. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-07 Completed Date: 2011-03-18 Revised Date: 2012-05-28 |
Medline Journal Info:
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Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 821-7 Citation Subset: IM |
Copyright Information:
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© 2010 APA, all rights reserved. |
Affiliation:
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Department of Ophthalmology and Visual Sciences and The Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Avoidance Learning / physiology Behavior, Animal / physiology* Carrier Proteins / genetics* Eye Proteins / genetics* Female Male Mice Mice, Knockout Photic Stimulation Vision, Ocular / physiology* Visual Acuity / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DE016511/DE/NIDCR NIH HHS; R01 DE016511-13A1/DE/NIDCR NIH HHS; R01 DE016511-17/DE/NIDCR NIH HHS; R01 EY017168-05/EY/NEI NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Eye Proteins; EC 3.1.1.64/retinoid isomerohydrolase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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