Document Detail

Light adaptation and the luminance-response function of the cone electroretinogram.
MedLine Citation:
PMID:  1633746     Owner:  NLM     Status:  MEDLINE    
Cone electroretinograms are typically isolated by presenting stimulus flashes against rod-desensitizing adapting fields. To investigate the manner in which adapting-field luminance affects cone electroretinogram response properties, we measured cone electroretinogram luminance-response functions of two normal subjects, with stimuli presented against adapting fields that ranged in luminance from -1.2 to 2.1 log cd/m2. A flicker rate of 31.1 Hz was used to isolate cone electroretinograms under all adaptation conditions. A hyperbolic equation of the form (R/Rmax) = Ln/(Ln + Kn) was fitted to each luminance-response function by a least-squares criterion. As adapting field luminance increased, the best-fit values of the variables K and n increased, which is in general agreement with results of electrophysiologic studies of light adaptation in retinal neurons. However, Rmax values also increased with adapting field luminance. The change in all three of these variables with adapting field luminance must be considered in the interpretation of cone electroretinogram luminance-response functions from patients with retinal disorders.
N S Peachey; K R Alexander; D J Derlacki; G A Fishman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Documenta ophthalmologica. Advances in ophthalmology     Volume:  79     ISSN:  0012-4486     ISO Abbreviation:  Doc Ophthalmol     Publication Date:  1992  
Date Detail:
Created Date:  1992-08-26     Completed Date:  1992-08-26     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0370667     Medline TA:  Doc Ophthalmol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  363-9     Citation Subset:  IM    
Hines Veterans Affairs Hospital, Ill.
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MeSH Terms
Adaptation, Ocular / physiology*
Middle Aged
Photic Stimulation
Photoreceptor Cells / physiology*
Grant Support

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