| Light-activated antibodies in the fight against primary and metastatic cancer. | |
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MedLine Citation:
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PMID: 20450983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The very cytotoxic potency of therapeutic antibodies used in the fight against cancer makes their specific tumour targeting of crucial importance. Unfortunately, in practice, this is often not achieved and can lead to dangerous side-effects. A way of greatly reducing such side-effects is to make the antibodies region-specific to the areas bearing tumour. This can now be achieved by rendering them light dependent so they are only active where illuminated. There are many ways of employing such light-enhanced targeting in very many locations within the body. When it is applied to direct killer T-cells to ovarian primary tumours, not only is primary tumour growth markedly reduced but also a dramatic reduction of metastatic growth is observed in the liver. |
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Authors:
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Stephen Thompson; Alexander C Self; Colin H Self |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-05-08 |
Journal Detail:
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Title: Drug discovery today Volume: 15 ISSN: 1878-5832 ISO Abbreviation: Drug Discov. Today Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9604391 Medline TA: Drug Discov Today Country: England |
Other Details:
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Languages: eng Pagination: 468-73 Citation Subset: IM |
Copyright Information:
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(c) 2010. Published by Elsevier Ltd. |
Affiliation:
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Diagnostic and Therapeutic Technologies, Institute of Cellular Medicine, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies / administration & dosage*, immunology Antineoplastic Agents / administration & dosage, adverse effects, pharmacology Drug Delivery Systems Humans Light* Neoplasm Metastasis Neoplasms / drug therapy*, immunology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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