Document Detail


Light-Controlled Toxicity of Engineered Amyloid β-Peptides.
MedLine Citation:
PMID:  23161824     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aggregation of amyloid β (Aβ(1-42) ), causing toxicity, is a critical step in Alzheimer's disease (AD). AD studies are difficult to compare because Aβ(1-42) aggregation is poorly controllable under physiological conditions. To control aggregation and toxicity, we engineered light-switchable Aβ(1-42) analogues that enable controllable conversion of nontoxic fibrils into toxic oligomers simply by illumination.
Authors:
Christian Hoppmann; Christian Barucker; Dorothea Lorenz; Gerd Multhaup; Michael Beyermann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-19
Journal Detail:
Title:  Chembiochem : a European journal of chemical biology     Volume:  -     ISSN:  1439-7633     ISO Abbreviation:  Chembiochem     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100937360     Medline TA:  Chembiochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Chemical Biology, Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10, 13125 Berlin (Germany); Current address: The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037-1099 (USA). choppmann@salk.edu.
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