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Light Activated Tissue Bonding for Excisional Wound Closure: A Split-Lesion Clinical Trial.
MedLine Citation:
PMID:  22032650     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Apposition of wound edges by sutures provides a temporary scaffold and tension support for healing. We have developed a novel tissue sealing technology, photoactivated tissue bonding (PTB) that immediately cross-links proteins between tissue planes thereby sealing on a molecular scale. Objectives:  To determine the effectiveness of PTB for superficial closure of skin excisions and to compare the results to standard epidermal suturing. Methods:  A split-lesion, paired comparison study of 31 skin excisions was performed. Following deep closure with absorbable sutures, one-half of each wound was superficially closed with non-absorbable nylon sutures while the other half was stained with Rose Bengal dye and treated with green light. Overall appearance and scar characteristics were rated at 2 weeks and 6 months in a blinded manner by three dermatologists viewing photographs, by two onsite physicians and by patients. Results:  At 2 weeks, neither sutured nor PTB-treated segments showed dehiscence; however, PTB-sealed segments showed less erythema than sutured segments as determined by photographic (p=0.001) and by onsite evaluations (p=0.005). Overall appearance after PTB was judged better than after sutures (p=0.002). At 6 months, scars produced by PTB was deemed superior to scars resulting from sutures in terms of appearance (p<0.001), width (p=0.002) and healing (p=0.003). Patients were more satisfied with the appearance of the PTB-sealed wound half after 2 weeks and 6 months (p=0.013; p=0.003). Conclusions:  A novel molecular suturing technique produces effective wound sealing and less scarring than closure with nylon interrupted epidermal sutures. Comparisons with better suturing techniques are warranted.
Authors:
S Tsao; M Yao; H Tsao; F P Henry; Y Zhao; J J Kochevar; R W Redmond; I E Kochevar
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-27
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 British Association of Dermatologists.
Affiliation:
Department of Dermatology Wellman Center for PhotomedicineMassachusetts General Hospital, Harvard Medical School, Boston MA USA.
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