| A light-activated theranostic nanoagent for targeted macrophage ablation in inflammatory atherosclerosis. | |
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MedLine Citation:
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PMID: 20721949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis and utility of a multimodal theranostic nanoagent based upon magnetofluorescent nanoparticles for the treatment of inflammatory atherosclerosis is described. These particles are modified with near-infrared fluorophores and light-activated therapeutic moieties, which allow for the optical determination of agent localization and phototoxic activation at spectrally distinct wavelengths. The resulting agent is readily taken up by murine macrophages in vitro and is highly phototoxic, with an LD(50) of 430 pM. Intravenous administration results in the localization of the nanoagent within macrophage-rich atherosclerotic lesions that can be imaged by intravital fluorescence microscopy. Irradiation of the atheroma with 650 nm light activates the therapeutic component and results in eradication of inflammatory macrophages, which may induce lesion stabilization. Importantly, these agents display limited skin photosensitivity, are highly efficacious, and provide an integrated imaging and therapeutic nanoplatform for atherosclerosis. |
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Authors:
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Jason R McCarthy; Ethan Korngold; Ralph Weissleder; Farouc A Jaffer |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Small (Weinheim an der Bergstrasse, Germany) Volume: 6 ISSN: 1613-6829 ISO Abbreviation: Small Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2011-02-02 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 101235338 Medline TA: Small Country: Germany |
Other Details:
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Languages: eng Pagination: 2041-9 Citation Subset: IM |
Affiliation:
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Harvard Medical School, Boston, MA 02114, USA. jason_mccarthy@hms.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apolipoproteins E / genetics Atherosclerosis / complications, pathology, therapy* Cell Separation / methods Cells, Cultured Drug Delivery Systems / methods* Female Inflammation / complications, pathology, therapy* Light Macrophages / drug effects*, pathology Male Mice Mice, Inbred C57BL Mice, Transgenic Models, Biological Nanostructures / administration & dosage, radiation effects, therapeutic use* Phototherapy / methods* |
| Grant Support | |
ID/Acronym/Agency:
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R21 HL093607-01A1/HL/NHLBI NIH HHS; R21HL093607/HL/NHLBI NIH HHS; U01-HL080731/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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