| Ligands for ErbB-family receptors encoded by a neuregulin-like gene. | |
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MedLine Citation:
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PMID: 9168114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuregulins (also called ARIA, GGF, heregulin or NDF) are a group of polypeptide factors that arise from alternative RNA splicing of a single gene. Through their interaction with the ErbB family of receptors (ErbB2, ErbB3 and ErbB4), neuregulins help to regulate cell growth and differentiation in many tissues. Here we report the cloning of a second neuregulin-like gene, neuregulin-2. The encoded product of the neuregulin-2 gene has a motif structure similar to that of neuregulins and an alternative splicing site in the epidermal growth factor(EGF)-like domain gives rise to two isoforms (alpha and beta). Northern blot and in situ hybridization analysis of adult rat tissues indicate that expression of neuregulin-2 is highest in the cerebellum, and the expression pattern is different from that of neuregulins. Recombinant neuregulin-2beta induces the tyrosine-phosphorylation of ErbB2, ErbB3 and ErbB4 in cell lines expressing all of these ErbB-family receptors. However, in cell lines with defined combinations of ErbBs, neuregulin-2beta only activates those with ErbB3 and/or ErbB4, suggesting that signalling by neuregulin-2 is mediated by ErbB3 and/or ErbB4 receptors. |
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Authors:
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H Chang; D J Riese; W Gilbert; D F Stern; U J McMahan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nature Volume: 387 ISSN: 0028-0836 ISO Abbreviation: Nature Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-06-19 Completed Date: 1997-06-19 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 509-12 Citation Subset: IM |
Affiliation:
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Department of Neurobiology, Stanford University School of Medicine, California 94305-5401, USA. hanchang@leland.stanford.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals CHO Cells Cell Line Cerebellum / metabolism Cloning, Molecular Cricetinae Glycoproteins / chemistry, genetics*, metabolism* In Situ Hybridization Ligands Molecular Sequence Data Neuregulins Phosphorylation Polymerase Chain Reaction Proto-Oncogene Proteins / metabolism* Rats Receptor, Epidermal Growth Factor / metabolism* Receptor, erbB-2 / metabolism* Receptor, erbB-3 Recombinant Proteins / metabolism Tissue Distribution Tyrosine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Ligands; 0/Neuregulins; 0/Proto-Oncogene Proteins; 0/Recombinant Proteins; 55520-40-6/Tyrosine; EC 2.7.10.1/Receptor, Epidermal Growth Factor; EC 2.7.10.1/Receptor, erbB-2; EC 2.7.10.1/Receptor, erbB-3; EC 2.7.10.1/receptor tyrosine-protein kinase erbB-4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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