Document Detail

Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye.
MedLine Citation:
PMID:  2004416     Owner:  NLM     Status:  MEDLINE    
Cell fate in the developing eye is determined by a cascade of inductive interactions. In this process, the sevenless protein--a receptor tyrosine kinase--is required for the specification of the R7 photoreceptor cell fate. We have constructed a gain-of-function sevenless mutation (SevS11) by overexpressing a truncated sevenless protein in the cells where sevenless is normally expressed. In SevS11 mutant flies, all sevenless-expressing cells initiate neural development. This results in the formation of multiple R7-like photoreceptors per ommatidium. Therefore, sevenless activity appears to be necessary and sufficient for the determination of R7 cell fate. These results illustrate the central role receptor tyrosine kinases can play in the specification of cell fate during development.
K Basler; B Christen; E Hafen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell     Volume:  64     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-19     Completed Date:  1991-04-19     Revised Date:  2012-06-01    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1069-81     Citation Subset:  IM    
Zoologisches Institut, Universität Zürich, Switzerland.
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MeSH Terms
Base Sequence
Drosophila / embryology*,  genetics
Drosophila Proteins*
Enhancer Elements, Genetic / genetics
Eye / embryology
Eye Proteins / physiology*
Gene Expression Regulation / physiology
Membrane Glycoproteins*
Membrane Proteins / physiology*
Molecular Sequence Data
Multigene Family
Neurons / cytology
Photoreceptor Cells / embryology
Protein-Tyrosine Kinases / genetics
Receptor Protein-Tyrosine Kinases*
Stem Cells / cytology,  enzymology
Reg. No./Substance:
0/Drosophila Proteins; 0/Eye Proteins; 0/Membrane Glycoproteins; 0/Membrane Proteins; EC Kinases; EC Protein-Tyrosine Kinases; EC protein, Drosophila

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