Document Detail


Ligand efficiency indices for effective drug discovery.
MedLine Citation:
PMID:  23484756     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Successful drug discovery requires the optimization of a large number of variables ranging from strictly physicochemical parameters such as molecular weight to more complex parameters related to toxicity and bioavailability. Presently, structure-based methodologies influence many aspects of the drug discovery process from lead discovery to the final preclinical characterization. However, critical biological issues along the path to the market have diminished the impact and power of this methodology. The physicochemical properties of the novel chemical entities designed and guided by structural methods have become the subject of intense scrutiny from lead discovery to drug candidate. The idea of ligand efficiency (binding energy/non-hydrogen atoms) has recently emerged as a useful guide to optimize fragment and lead selection in the discovery process. More generalized concepts of ligand efficiency, related to efficiency per dalton and per unit of polar surface area, have also been introduced and will be discussed in the broader context. Preliminary results and trends obtained using ligand efficiencies as guides are reviewed and their future application to guide drug discovery will be discussed, as well as their integration into the structure-based drug design methods to make them more effective and numerically robust.
Authors:
Cele Abad-Zapatero
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert opinion on drug discovery     Volume:  2     ISSN:  1746-0441     ISO Abbreviation:  Expert Opin Drug Discov     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2013-03-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101295755     Medline TA:  Expert Opin Drug Discov     Country:  England    
Other Details:
Languages:  eng     Pagination:  469-88     Citation Subset:  -    
Affiliation:
Center for Pharmaceutical Biotechnology, Molecular Biology Research Building, Room 3152, University of Illinois at Chicago, 900 So. Ashland St. m/c 870, Chicago, IL 60607-7173, USA; E-mail: caz@uic.edu.
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