Document Detail


Ligand-decorated nanogels: fast one-pot synthesis and cellular targeting.
MedLine Citation:
PMID:  22455467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nanoscale vehicles for delivery have been of interest and extensively studied for two decades. However, the encapsulation stability of hydrophobic drug molecules in delivery vehicles and selective targeting these vehicles into disease cells are potential hurdles for efficient delivery systems. Here we demonstrate a simple and fast synthetic protocol of nanogels that shows high encapsulation stabilities. These nanogels can also be modified with various targeting ligands for active targeting. We show that the targeting nanogels (T-NGs), which are prepared within 2 h by a one-pot synthesis, exhibit very narrow size distributions and have the versatility of surface modification with cysteine-modified ligands including folic acid, cyclic arginine-glycine-aspartic acid (cRGD) peptide, and cell-penetrating peptide. T-NGs hold their payloads, undergo facilitated cell internalization by receptor-mediated uptake, and release their drug content inside cells due to the reducing intracellular environment. Selective cytotoxicity to cells, which have complementary receptors, is also demonstrated.
Authors:
Ja-Hyoung Ryu; Sean Bickerton; Jiaming Zhuang; S Thayumanavan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-04-11
Journal Detail:
Title:  Biomacromolecules     Volume:  13     ISSN:  1526-4602     ISO Abbreviation:  Biomacromolecules     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-14     Completed Date:  2012-09-17     Revised Date:  2014-08-17    
Medline Journal Info:
Nlm Unique ID:  100892849     Medline TA:  Biomacromolecules     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1515-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Capsules / chemical synthesis,  chemistry
Cell-Penetrating Peptides / chemistry*
Cells, Cultured
Drug Carriers / chemical synthesis,  chemistry*
Drug Delivery Systems
Drug Stability
Folic Acid / chemistry*
Gels / chemical synthesis,  chemistry*
HEK293 Cells
HeLa Cells
Humans
Ligands
Nanostructures / chemistry*
Oligopeptides / chemistry*
Grant Support
ID/Acronym/Agency:
T32 GM008515/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Capsules; 0/Cell-Penetrating Peptides; 0/Drug Carriers; 0/Gels; 0/Ligands; 0/Oligopeptides; 935E97BOY8/Folic Acid; 99896-85-2/arginyl-glycyl-aspartic acid
Comments/Corrections

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