Document Detail


Lifetime risk and age at diagnosis of symptomatic knee osteoarthritis in the US.
MedLine Citation:
PMID:  23203864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To estimate the incidence and lifetime risk of diagnosed symptomatic knee osteoarthritis (OA) and the age at diagnosis of knee OA based on self-reports in the US population.
METHODS: We estimated the incidence of diagnosed symptomatic knee OA in the US by combining data on age-, sex-, and obesity-specific prevalence from the 2007-2008 National Health Interview Survey, with disease duration estimates derived from the Osteoarthritis Policy (OAPol) Model, a validated computer simulation model of knee OA. We used the OAPol Model to estimate the mean and median ages at diagnosis and lifetime risk.
RESULTS: The estimated incidence of diagnosed symptomatic knee OA was highest among adults ages 55-64 years, ranging from 0.37% per year for nonobese men to 1.02% per year for obese women. The estimated median age at knee OA diagnosis was 55 years. The estimated lifetime risk was 13.83%, ranging from 9.60% for nonobese men to 23.87% in obese women. Approximately 9.29% of the US population is diagnosed with symptomatic knee OA by age 60 years.
CONCLUSION: The diagnosis of symptomatic knee OA occurs relatively early in life, suggesting that prevention programs should be offered relatively early in the life course. Further research is needed to understand the future burden of health care utilization resulting from earlier diagnosis of knee OA.
Authors:
Elena Losina; Alexander M Weinstein; William M Reichmann; Sara A Burbine; Daniel H Solomon; Meghan E Daigle; Benjamin N Rome; Stephanie P Chen; David J Hunter; Lisa G Suter; Joanne M Jordan; Jeffrey N Katz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arthritis care & research     Volume:  65     ISSN:  2151-4658     ISO Abbreviation:  Arthritis Care Res (Hoboken)     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-24     Completed Date:  2013-06-17     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  703-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 by the American College of Rheumatology.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Aged, 80 and over
Cohort Studies
Cross-Sectional Studies / trends
Female
Humans
Longevity*
Male
Middle Aged
Osteoarthritis, Knee / diagnosis*,  epidemiology*
Risk Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
HHSM-500-2008-0025I/HHSM-500-T0001//PHS HHS; K23-AR054095/AR/NIAMS NIH HHS; K24 AR057827/AR/NIAMS NIH HHS; K24-AR057827/AR/NIAMS NIH HHS; P60 AR047782/AR/NIAMS NIH HHS; P60-AR47782/AR/NIAMS NIH HHS; R01 AR053112/AR/NIAMS NIH HHS; R01-AR053112/AR/NIAMS NIH HHS; T32-AR-055885/AR/NIAMS NIH HHS
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