Document Detail

Lifetime prognosis of juvenile myoclonic epilepsy.
MedLine Citation:
PMID:  23756474     Owner:  NLM     Status:  In-Data-Review    
Juvenile myoclonic epilepsy (JME) is among the most common types of genetic epilepsies, displaying a good prognosis when treated with appropriate drugs, but with a well-known tendency to relapse after withdrawal. The majority of patients with JME have continuing seizures after a follow-up of two decades. However, 17% are able to discontinue medication and remain seizure-free thereafter. Clinicians should remember that there is a small but still considerable subgroup of JME patients whose seizures are difficult to treat before informing patients with newly-diagnosed JME about their "benign" prognosis. This resistant course is not fully explained, though there are many suggested factors. The dominating myoclonic seizures disappear or diminish in severity in the fourth decade of life. Despite the favorable seizure outcome in most of the cases, 3/4 of patients with JME have at least one major unfavorable social outcome. The possible subsyndromes of JME, its genetic background, and its pathophysiological and neuroimaging correlates should be further investigated. This article is part of a supplemental special issue entitled Juvenile Myoclonic Epilepsy: What is it Really?
Betul Baykan; Iris E Martínez-Juárez; Ebru A Altindag; Carol S Camfield; Peter R Camfield
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  28 Suppl 1     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S18-24     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Istanbul University Epilepsy Center and Istanbul Faculty of Medicine, Department of Neurology, Istanbul, Turkey. Electronic address:
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