Document Detail


Lifetime history of traumatic events in an American Indian community sample: heritability and relation to substance dependence, affective disorder, conduct disorder and PTSD.
MedLine Citation:
PMID:  23102628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
American Indians appear to experience a higher rate of traumatic events than what has been reported in general population surveys. American Indians also suffer higher alcohol related death rates than any other ethnic group in the U.S. population. Therefore efforts to delineate factors which may uniquely contribute to increased likelihood of trauma, post traumatic stress disorder (PTSD), and substance use disorders (SUD) over the lifetime in American Indians are important because of the high burden of morbidity and mortality that they pose to American Indian communities. Participants were American Indians recruited from reservations that were assessed with the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA), family history assessment and the stressful-life-events scale. Of the 309 participants, equivalent numbers of men and women (94%) reported experiencing traumas; however, a larger proportion of women received a PTSD diagnosis (38%) than men (29%). Having experienced multiple trauma and sexual abuse were most highly associated with PTSD. Having experienced assaultive trauma and having PTSD symptoms were both found to be moderately heritable (30-50%). Logistic regression revealed that having an anxiety and/or affective disorder and having a substance dependent diagnosis, but not having antisocial personality disorder/conduct disorder, were significantly correlated with having a diagnosis of PTSD. These studies suggest that trauma is highly prevalent in this American Indian community, it is heritable, is associated with PTSD, affective/anxiety disorders and substance dependence. Additionally, trauma, PTSD and substance dependence appear to all co-emerge in early adulthood in this high-risk population.
Authors:
Cindy L Ehlers; Ian R Gizer; David A Gilder; Rachael Yehuda
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-24
Journal Detail:
Title:  Journal of psychiatric research     Volume:  47     ISSN:  1879-1379     ISO Abbreviation:  J Psychiatr Res     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-12-25     Completed Date:  2013-06-07     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  155-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Conduct Disorder / epidemiology*,  psychology
Female
Humans
Indians, North American* / psychology,  statistics & numerical data
Male
Middle Aged
Mood Disorders / epidemiology*,  psychology
Psychiatric Status Rating Scales
Residence Characteristics
Stress Disorders, Post-Traumatic / epidemiology*,  psychology
Substance-Related Disorders / epidemiology*,  psychology
Young Adult
Grant Support
ID/Acronym/Agency:
5R37 AA010201/AA/NIAAA NIH HHS; DA030976/DA/NIDA NIH HHS; R01 AA010201/AA/NIAAA NIH HHS; R01 DA030976/DA/NIDA NIH HHS; R37 AA010201/AA/NIAAA NIH HHS
Comments/Corrections

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