| Lifetime course of myasthenia gravis. | |
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MedLine Citation:
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PMID: 18059039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Between 1940 and 2000 a total of 1976 patients with myasthenia gravis (MG) were studied. Diagnosis was made by improvement in weakness after anticholinesterase medication. The historical developments in diagnosis and treatment of MG are reviewed. We analyzed the clinical course of MG as influenced by age, gender, thymectomy, thymomectomy, and the presence of antibodies to acetylcholine receptors (AChR). The clinical course of MG was significantly influenced by age and gender, and these need special attention in managing patients. The most severe level of weakness and high mortality occurred during the first 1 to 2 years of the disease, after which many patients experienced improvement. For treating MG patients the usefulness of thymectomy remains to be proven, and novel drugs need to be developed to increase the number as well as normal functioning of the AChRs and other components of the neuromuscular system. |
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Authors:
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David Grob; Norman Brunner; Tatsuji Namba; Murali Pagala |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Muscle & nerve Volume: 37 ISSN: 0148-639X ISO Abbreviation: Muscle Nerve Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-05 Completed Date: 2008-04-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 141-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Maimonides Medical Center, Brooklyn, New York 11219, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Aged Aged, 80 and over Disease Progression Female Humans Male Middle Aged Myasthenia Gravis / epidemiology*, mortality, physiopathology*, therapy Receptors, Cholinergic / immunology Retrospective Studies Sex Factors Thymectomy / methods |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Cholinergic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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