Document Detail

Lifetime course of eating disorders: design and validity testing of a new strategy to define the eating disorders phenotype.
MedLine Citation:
PMID:  18377676     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Aetiological studies of eating disorders would benefit from a solution to the problem of instability of eating disorder symptoms. We present an approach to defining an eating disorders phenotype based on the retrospective assessment of lifetime eating disorders symptoms to define a lifetime pattern of illness. We further validate this approach by testing the most common lifetime categories for differences in the prevalence of specific childhood personality traits. METHOD: Ninety-seven females participated in this study, 35 with a current diagnosis of restricting anorexia nervosa, 32 with binge/purging subtype of anorexia nervosa and 30 with bulimia nervosa. Subjects were interviewed by a newly developed EATATE Lifetime Diagnostic Interview for a retrospective assessment of the lifetime course of eating disorders symptoms and childhood traits reflecting obsessive-compulsive personality. RESULTS: The data illustrate the extensive instability of the eating disorders diagnosis. Four most common lifetime diagnostic categories were identified that significantly differ in the prevalence of childhood traits. Perfectionism and rigidity were more common in groups with a longer duration of underweight status, longer episodes of severe food restriction, excessive exercising, and shorter duration of binge eating. CONCLUSIONS: The assessment of lifetime symptoms may produce a more accurate definition of the eating disorders phenotype. Obsessive-compulsive traits in childhood may moderate the course producing longer periods of underweight status. These findings may have important implications for nosology, treatment and future aetiological studies of eating disorders.
M Anderluh; K Tchanturia; S Rabe-Hesketh; D Collier; J Treasure
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2008-04-01
Journal Detail:
Title:  Psychological medicine     Volume:  39     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-03-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  105-14     Citation Subset:  IM    
Eating Disorders Unit, Institute of Psychiatry, King's College London, London, UK.
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MeSH Terms
Chronic Disease
Eating Disorders / diagnosis*,  epidemiology,  psychology*
Interview, Psychological / methods*,  standards*
London / epidemiology
Obsessive-Compulsive Disorder / epidemiology,  psychology
Personality Assessment / statistics & numerical data
Reproducibility of Results
Retrospective Studies
Severity of Illness Index
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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