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MedLine Citation:
PMID:  23230068     Owner:  NLM     Status:  Publisher    
OBJECTIVES:Blood pressure tracks from adolescence to adulthood and is positively associated with low birth weight and faster infant growth. Most observations are from Western populations; it is unclear whether these are biologically based or contextually specific. We examined the associations of growth with blood pressure in adolescence.METHODS:Multivariable partial least squares regression was used to assess the associations of growth to ∼11 years with blood pressure at ∼11 years in 5813 term births from Hong Kong's Children of 1997 birth cohort. Growth was considered as gender- and age-specific z-scores for birth weight, BMI, and length at 3 months; change in z-scores for BMI and height at 3 to 9 months, 9 to 36 months, 3 to 7 years, and 7 to 11 years; and BMI and height at 11 years.RESULTS:Birth weight was weakly inversely associated with systolic blood pressure in girls -0.58 mm Hg 95% confidence interval -1.05 to -0.12 (boys -0.21, -0.71 to 0.30). Childhood growth, particularly linear growth at 7 to 11 years (girls: 1.27, 0.56 to 1.98; boys 2.11, 1.39 to 2.83), as well as current height (girls: 2.40, 2.04 to 2.76, boys: 2.65, 2.29 to 3.01) and BMI (girls: 2.72, 2.35 to 3.09, boys: 2.72, 2.09 to 3.36) were associated with higher systolic blood pressure. Diastolic blood pressure was also positively associated with current size.CONCLUSIONS:In the first study to examine simultaneously the role of pre- and postnatal growth in adolescent blood pressure, the role of late childhood growth predominated.
Michelle Heys; Shi Lin Lin; Tai Hing Lam; Gabriel M Leung; C Mary Schooling
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-10
Journal Detail:
Title:  Pediatrics     Volume:  -     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Lifestyle and Life Course Epidemiology Group, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;
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