Document Detail

Lifestyle intervention improves microvascular reactivity and increases serum adiponectin in overweight hypertensive patients.
MedLine Citation:
PMID:  19473823     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Obesity and hypoadiponectinemia are often associated with high blood pressure. Moreover, microvascular dysfunction is reported to be an early event in patients with hypertension and may be involved in the pathogenesis of organ damage.
METHODS AND RESULTS: We investigated the impact of 8-week moderate-intensity aerobic training on adiponectin plasma levels and skin microvascular reactivity in 24 overweight sedentary patients (18 men, age 44+/-6 years, body mass index 28+/-3 kg/m(2)) with never-treated grade 1 essential hypertension. Twenty-four age- and sex-matched hypertensive patients, who were examined twice at 8-week intervals in the absence of exercise training, served as controls. Exercise training was followed by a significant reduction in waist circumference (from 97+/-9 to 95+/-9 cm, p<0.05) and an increase in adiponectin plasma levels (from 11.9+/-3 to 12.5+/-4 mg/L, p<0.05). An inverse correlation was found between adiponectin change and waist circumference change (r=-0.43, p<0.05). The area under the curve after post-occlusive reactive hyperemia at skin laser-Doppler examination increased significantly after aerobic training (from 876+/-539 to 1468+/-925 PU/s, p<0.001). A positive correlation was found between exercise-induced variations of post-occlusive reactive hyperemia and adiponectin plasma levels (r=0.41, p<0.05). Office or 24-h blood pressure values did not change significantly.
CONCLUSION: In sedentary overweight patients with mild hypertension, moderate aerobic training improves cutaneous microvascular reactivity and adiponectin plasma levels. These changes precede blood pressure reduction and may serve as biomarkers of the efficacy of non-drug treatment in hypertensive patients.
L Pasqualini; G Schillaci; S Innocente; G Pucci; F Coscia; D Siepi; G Lupattelli; G Ciuffetti; E Mannarino
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2009-05-26
Journal Detail:
Title:  Nutrition, metabolism, and cardiovascular diseases : NMCD     Volume:  20     ISSN:  1590-3729     ISO Abbreviation:  Nutr Metab Cardiovasc Dis     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-04-29     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  9111474     Medline TA:  Nutr Metab Cardiovasc Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier B.V. All rights reserved.
Department of Clinical and Experimental Medicine, University of Perugia School of Medicine, Hospital Santa Maria della Misericordia, Perugia, Italy.
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MeSH Terms
Adiponectin / blood
Biological Markers / blood
Blood Pressure
Exercise Therapy*
Hyperemia / physiopathology
Hypertension / blood,  complications,  physiopathology,  therapy*
Laser-Doppler Flowmetry
Middle Aged
Overweight / blood,  complications,  physiopathology,  therapy*
Sedentary Lifestyle*
Skin / blood supply*
Time Factors
Treatment Outcome
Waist Circumference
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers

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