Document Detail

Lifestyle during pregnancy: neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study.
MedLine Citation:
PMID:  20064917     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been suggested that even mild exposure to alcohol, caffeine, smoking, and poor diet may have adverse long-term neurodevelopmental effects. In addition, there is evidence that timing of high exposures (e.g. binge drinking) can have particularly negative effects. This paper describes the design and implementation of The Lifestyle During Pregnancy Study addressing major methodological challenges for studies in this field. The study examines the effects of lifestyle during pregnancy on offspring neurodevelopment. METHODS: In 2003, we initiated a prospective follow-up of 1750 mother-child pairs, sampled on the basis of maternal alcohol drinking patterns from The Danish National Birth Cohort (DNBC), a study of 101,042 pregnancies enrolled 1997-2003. Data collection in the DNBC involved four prenatal and postnatal maternal interviews, providing detailed information on maternal alcohol drinking patterns before and during pregnancy, caffeine intake, smoking, diet, and other lifestyle, medical, and sociodemographic factors. RESULTS: At the age of 5 years, the children and their mothers participated in a comprehensive assessment of neurobehavioural development focusing on global cognition, specific cognitive functions, and behaviour. Two new tests assessing attention and speed of information processing among children were developed, and data on important potential confounders such as maternal intelligence quotient, vision, and hearing abilities were collected. Efforts were made to standardise procedures and obtain high inter-rater reliability. CONCLUSIONS: We expect that the study will illuminate the significance or lack of significance of maternal lifestyle during pregnancy and contribute to better understanding the effects of alcohol drinking during pregnancy at low to moderate consumption levels.
Ulrik Schi?ler Kesmodel; Mette Underbjerg; Tina R?ndrup Kilburn; Leiv Bakketeig; Erik Lykke Mortensen; Nils Inge Landr?; Diana Schendel; Jacquelyn Bertrand; Jakob Grove; Shahul Ebrahim; Poul Thorsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2010-01-11
Journal Detail:
Title:  Scandinavian journal of public health     Volume:  38     ISSN:  1651-1905     ISO Abbreviation:  Scand J Public Health     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-23     Completed Date:  2010-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883503     Medline TA:  Scand J Public Health     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  208-19     Citation Subset:  IM    
School of Public Health, Department of Epidemiology, University of Aarhus, Denmark.
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MeSH Terms
Alcohol Drinking / adverse effects*
Child Behavior Disorders / etiology*
Child Development*
Child, Preschool
Cognition Disorders / etiology*
Cohort Studies
Follow-Up Studies
Food Habits
Life Style*
Maternal Exposure / adverse effects*
Psychomotor Performance
Smoking / adverse effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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