| Lifestyle Change and High-Density Lipoprotein Change: The US Department of Veterans Affairs Normative Aging Study. | |
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MedLine Citation:
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PMID: 22407520 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: We sought to determine whether lifestyle modifications are associated with high-density lipoprotein cholesterol (HDL-C) change in a cohort with long-term follow-up. HYPOTHESIS: Changes in alcohol consumption, smoking, or body mass index (BMI) are associated with within-individual changes in HDL-C. METHODS: We selected 1420 men with ≥2 HDL-C measurements from the US Department of Veterans Affairs Normative Aging Study (NAS). Changes in HDL-C (in milligrams/deciliter) over a 3-year period were calculated for each pair of exams. For each interval of HDL-C change, lifestyle exposures were categorized: participants maintained a stable BMI >25 kg/m(2) (reference) or ≤25 kg/m(2) since the previous exam, or increased or decreased BMI; participants were actively smoking at both exams (reference), nonsmokers at both exams, quit, or initiated smoking between exams; and participants maintained alcohol intake of <2 (reference) or ≥2 drinks daily since the previous exam, or increased or decreased alcohol intake. Longitudinal analysis was used to examine the relationship between the lifestyle change categories and 3-year change in HDL-C for each interval, adjusting for comorbidities, lipids, and cholesterol medication. RESULTS: Participants were followed for approximately 14.3 years. Increases in HDL-C were associated with maintaining alcohol intake of ≥2 drinks daily (mean HDL-C increase, 0.86; P = 0.02), increasing alcohol intake from <2 to ≥2 drinks daily (mean, 2.53; P = 0.0003), and with maintaining a BMI of ≤25 kg/m(2) (mean, 0.71; P = 0.04). CONCLUSIONS: Increases in alcohol consumption, maintaining moderate alcohol intake, and maintaining BMI ≤25 kg/m(2) were associated with significant 3-year increases in HDL-C. Clin. Cardiol. 2012 DOI: 10.1002/clc.21978 The VA NAS is sponsored by the Cooperative Studies Program/ERIC, US Department of Veterans Affairs. This research was also supported by a VA Merit Review and a VA Research Career Scientist award to Avron Spiro. The authors have no other funding, financial relationships, or conflicts of interest to disclose. |
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Authors:
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Catherine Rahilly-Tierney; Pantel Vokonas; J Michael Gaziano; Avron Spiro |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-8 |
Journal Detail:
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Title: Clinical cardiology Volume: - ISSN: 1932-8737 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Wiley Periodicals, Inc. |
Affiliation:
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Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC), Boston VA Healthcare System, Boston, Massachusetts; Division of Aging, Brigham and Women's Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Department of Medicine, Boston University, Boston, Massachusetts. crahilly-tierney@partners.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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