Document Detail

Lifelong physical activity preserves functional sympatholysis and purinergic signalling in the ageing human leg.
MedLine Citation:
PMID:  22966164     Owner:  NLM     Status:  MEDLINE    
Ageing is associated with an impaired ability to modulate sympathetic vasoconstrictor activity (functional sympatholysis) and a reduced exercise hyperaemia. The purpose of this study was to investigate whether a physically active lifestyle can offset the impaired functional sympatholysis and exercise hyperaemia in the leg and whether ATP signalling is altered by ageing and physical activity. Leg haemodynamics, interstitial [ATP] and P2Y(2) receptor content was determined in eight young (23 ± 1 years), eight lifelong sedentary elderly (66 ± 2 years) and eight lifelong active elderly (62 ± 2 years) men at rest and during one-legged knee extensions (12 W and 45% maximal workload (WL(max))) and arterial infusion of ACh and ATP with and without tyramine. The vasodilatory response to ACh was lowest in the sedentary elderly, higher in active elderly (P < 0.05) and highest in the young men (P < 0.05), whereas ATP-induced vasodilatation was lower in the sedentary elderly (P < 0.05). During exercise (12 W), leg blood flow, vascular conductance and VO2 was lower and leg lactate release higher in the sedentary elderly compared to the young (P < 0.05), whereas there was no difference between the active elderly and young. Interstitial [ATP] during exercise and P2Y(2) receptor content were higher in the active elderly compared to the sedentary elderly (P < 0.05). Tyramine infusion lowered resting vascular conductance in all groups, but only in the sedentary elderly during exercise (P < 0.05). Tyramine did not alter the vasodilator response to ATP infusion in any of the three groups. Plasma [noradrenaline] increased more during tyramine infusion in both elderly groups compared to young (P < 0.05). A lifelong physically active lifestyle can maintain an intact functional sympatholysis during exercise and vasodilator response to ATP despite a reduction in endothelial nitric oxide function. A physically active lifestyle increases interstitial ATP levels and skeletal muscle P2Y(2) receptor content.
S P Mortensen; M Nyberg; K Winding; B Saltin
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-10
Journal Detail:
Title:  The Journal of physiology     Volume:  590     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-17     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  6227-36     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / pharmacology
Adenosine Triphosphate / pharmacology
Aging / physiology*
Endothelium, Vascular / physiopathology
Epinephrine / blood
Exercise / physiology*
Femoral Artery / physiology
Hyperemia / physiopathology
Leg / physiology*
Middle Aged
Muscle, Skeletal / physiology
Norepinephrine / blood
Receptors, Purinergic P2Y2 / physiology
Young Adult
Reg. No./Substance:
0/Receptors, Purinergic P2Y2; 8L70Q75FXE/Adenosine Triphosphate; N9YNS0M02X/Acetylcholine; X4W3ENH1CV/Norepinephrine; YKH834O4BH/Epinephrine
Comment In:
J Physiol. 2012 Dec 1;590(Pt 23):5927-8   [PMID:  23204098 ]

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