Document Detail

Lifecourse relationship between maternal smoking during pregnancy, birth weight, contemporaneous anthropometric measurements and bone mass at 18years old. The 1993 Pelotas Birth Cohort.
MedLine Citation:
PMID:  25463840     Owner:  NLM     Status:  Publisher    
BACKGROUND: Maternal smoking during pregnancy is associated with short-term and also long-term harmful effects on offspring.
OBJECTIVE: The aim of this study is to evaluate the associations of maternal smoking during pregnancy with offspring bone health at 18years old, and the role of birth weight and contemporaneous height, weight and body mass index (BMI) in this association. Data from the 1993 Pelotas Birth Cohort were analyzed using path analysis stratified by sex. Adolescents at 18years old (N=1512 males, 1563 females). DXA-determined total body bone mineral density (BMD) and bone mineral content (BMC) were assessed at 18years old.
RESULTS: Each additional cigarette smoked during pregnancy was associated with a lower BMC by -4.20g in males (95% CI -8.37; -0.05), but not in females [-2.22g (95% CI -5.49; 1.04)]; weaker inverse associations were observed for BMD. This inverse association was explained by the influence of maternal smoking on birth weight and contemporaneous anthropometry, particularly height. A 1kg higher birth weight was associated with a higher BMC by around 144g in males and by around 186g in females, and also with a higher BMD by around 0.019g/cm(2) in males and by around 0.018g/cm(2) in females, respectively.
CONCLUSIONS: Lifecourse analysis using path models has enabled to evaluate the role of mediators in the associations of maternal smoking during pregnancy and birth weight with bone mass in the offspring, thus generating improved understanding of the etiology of bone health and the importance of early life experiences.
Jeovany Martínez-Mesa; Ana Maria Baptista Menezes; Laura D Howe; Fernando Cesar Wehrmeister; Ludmila Correia Muniz; David Alejandro González-Chica; Maria Cecilia Assunção; Helen Gonçalves; Fernando C Barros
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-6
Journal Detail:
Title:  Early human development     Volume:  90     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-2     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  901-906     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ireland Ltd.
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