Document Detail

A Life under Pressure: Circumferential Sstress in the Mmicrovascular wall.
MedLine Citation:
PMID:  21917118     Owner:  NLM     Status:  Publisher    
Micro-vessels live "a life under pressure" in several ways. In a literal sense, vessels of the microcirculation are exposed to high levels of stress caused primarily by the intravascular pressure head. In a figurative sense, the individual vessel and the microvascular network as a whole must continuously strive to meet the changing demands of the surrounding tissue. The "principle of optimal operation" as formulated by Y.C. Fung states that living tissues adapts structurally through remodeling and growth until a level of tensile and compressive stresses is reached at which tissue performance is optimal. This behaviour is characteristic for the microvascular wall. It is highly plastic by nature and meets sustained changes by structural adaptation so as to maintain functional optimality. Due to the orientation of the vascular smooth muscle cell in the media, in particular the circumferential stress component has a huge impact on the state of the vascular wall. It is involved as a unifying factor on vastly different timescales in processes as diverse as acute regulation of vessel diameter, structural vessel remodeling and growth or atrophy of the vascular wall. The aim of the present MiniReview is to outline in brief this integrative role of circumferential wall stress in the microcirculation.
Jens Christian Brings Jacobsen; Niels-Henrik Holstein-Rathlou
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-15
Journal Detail:
Title:  Basic & clinical pharmacology & toxicology     Volume:  -     ISSN:  1742-7843     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208422     Medline TA:  Basic Clin Pharmacol Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Basic & Clinical Pharmacology & Toxicology © 2011 Nordic Pharmacological Society.
The Department of Biomedical Sciences, University of Copenhagen, Denmark.
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