Document Detail

Life trajectories, genetic testing, and risk reduction decisions in 18-39 year old women at risk for hereditary breast and ovarian cancer.
MedLine Citation:
PMID:  18979190     Owner:  NLM     Status:  MEDLINE    
This qualitative study identified four life trajectories that influenced the decision in young women to have genetic testing for mutations in BRCA1/2 and subsequent risk reduction decisions after receiving a positive mutation result. Fifty nine women between the ages of 18-39 years were interviewed in this grounded theory study, 44 of those tested were found to have a mutation in either BRCA1 or BRCA2. Of those with a mutation, 23 had no history of cancer and 21 had a breast cancer diagnosis. Analysis of the 44 participants tested found that risk reducing decisions were related to the life trajectories that preceded genetic testing. These life trajectories included: 1) Long-standing awareness of breast cancer in the family, 2) Loss of one's mother to breast cancer at a young age, 3) Expression of concern by a health care provider, and 4) Personal diagnosis of breast cancer. Understanding possible influences behind decision making for genetic testing and risk reduction in young women may assist health care providers in offering age appropriate guidance and support.
Rebekah Hamilton; Janet K Williams; Barbara J Bowers; Kathleen Calzone
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-11-01
Journal Detail:
Title:  Journal of genetic counseling     Volume:  18     ISSN:  1573-3599     ISO Abbreviation:  J Genet Couns     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-13     Completed Date:  2009-05-28     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  9206865     Medline TA:  J Genet Couns     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-59     Citation Subset:  IM    
Women, Children and Family Health Sciences, University of Illinois, Chicago, IL 60612, USA.
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MeSH Terms
Breast Neoplasms / genetics*
Genes, BRCA2
Genetic Predisposition to Disease*
Genetic Testing*
Ovarian Neoplasms / genetics*
Risk Reduction Behavior
Grant Support
1 RO3NR009483-01/NR/NINR NIH HHS; R03 NR009483-01/NR/NINR NIH HHS

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