Document Detail

Life-threatening ventricular arrhythmia (torsades de pointes) after haloperidol overdose.
MedLine Citation:
PMID:  1673626     Owner:  NLM     Status:  MEDLINE    
A 48-year-old woman developed QT prolongation and episodes of life-threatening ventricular tachycardia (torsades de pointes) after intentional overdose of haloperidol and orphenadrine. The arrhythmia did not respond to conventional anti-arrhythmic therapy but was suppressed by atrial overdrive pacing. A literature review identified haloperidol as the most likely cause of the torsades de pointes.
R A Henderson; S Lane; J A Henry
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human & experimental toxicology     Volume:  10     ISSN:  0960-3271     ISO Abbreviation:  Hum Exp Toxicol     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-06-06     Completed Date:  1991-06-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9004560     Medline TA:  Hum Exp Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  59-62     Citation Subset:  IM    
Guy's Hospital, London, UK.
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MeSH Terms
Electrocardiography / drug effects
Haloperidol / poisoning*
Middle Aged
Orphenadrine / poisoning
Overdose / complications
Torsades de Pointes / chemically induced*
Ventricular Function / drug effects
Reg. No./Substance:
52-86-8/Haloperidol; 83-98-7/Orphenadrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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