| Life-threatening splenic hemorrhage in two patients with Gaucher disease. | |
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MedLine Citation:
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PMID: 10814997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Massive splenomegaly is a frequent finding in patients with Gaucher disease, the most common of the sphingolipidoses. Even so, the risk for splenic rupture and intracapsular hemorrhage has not been emphasized due to the rarity of this occurrence and the fibrotic, rubbery consistency of splenic tissue in these patients. We report two adult patients with type 1 Gaucher disease who suffered life-threatening splenic bleeds that were not acutely diagnosed. Both patients ultimately required emergent splenectomies. Factors complicating the diagnosis of splenic hemorrhage in patients with Gaucher disease are discussed. Published 2000 Wiley-Liss, Inc. |
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Authors:
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D L Stone; E I Ginns; D Krasnewich; E Sidransky |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of hematology Volume: 64 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-06-21 Completed Date: 2000-06-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 140-2 Citation Subset: IM |
Affiliation:
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Clinical Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Critical Illness* Emergency Medical Services Gaucher Disease / complications* Hemorrhage / complications*, radiography, surgery Humans Male Middle Aged Splenectomy Splenic Diseases / complications*, radiography, surgery Tomography, X-Ray Computed |
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