Document Detail


Life-threatening splenic hemorrhage in two patients with Gaucher disease.
MedLine Citation:
PMID:  10814997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Massive splenomegaly is a frequent finding in patients with Gaucher disease, the most common of the sphingolipidoses. Even so, the risk for splenic rupture and intracapsular hemorrhage has not been emphasized due to the rarity of this occurrence and the fibrotic, rubbery consistency of splenic tissue in these patients. We report two adult patients with type 1 Gaucher disease who suffered life-threatening splenic bleeds that were not acutely diagnosed. Both patients ultimately required emergent splenectomies. Factors complicating the diagnosis of splenic hemorrhage in patients with Gaucher disease are discussed. Published 2000 Wiley-Liss, Inc.
Authors:
D L Stone; E I Ginns; D Krasnewich; E Sidransky
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  64     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-06-21     Completed Date:  2000-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  140-2     Citation Subset:  IM    
Affiliation:
Clinical Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Critical Illness*
Emergency Medical Services
Gaucher Disease / complications*
Hemorrhage / complications*,  radiography,  surgery
Humans
Male
Middle Aged
Splenectomy
Splenic Diseases / complications*,  radiography,  surgery
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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