| Life-threatening organ failure after lamotrigine therapy. | |
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MedLine Citation:
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PMID: 19380079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe an 11-year-old girl with a seizure disorder who developed fever, rash, rhabdomyolysis, and multiorgan failure 2 weeks after commencing a transition from sodium valproate to lamotrigine therapy. To our knowledge, this patient represents the most severe life-threatening hypersensitivity lamotrigine reaction described in the pediatric literature. We recommend caution when prescribing lamotrigine to children on concomitant sodium valproate, and immediate discontinuation of lamotrigine and the provision of aggressive supportive care in patients with features of lamotrigine hypersensitivity. |
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Authors:
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Lee P Ferguson; Paul I Dargan; Joanne L Hood; Shane M Tibby |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 40 ISSN: 1873-5150 ISO Abbreviation: Pediatr. Neurol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-21 Completed Date: 2009-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 392-4 Citation Subset: IM |
Affiliation:
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Department of Pediatric Intensive Care, Evelina Children's Hospital, Guy's and Saint Thomas' National Health Service Foundation Trust, London, United Kingdom. lee.ferguson@childrens.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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contraindications* Child Drug Therapy, Combination Exanthema / chemically induced Female Fever / chemically induced Humans Multiple Organ Failure / chemically induced*, therapy Rhabdomyolysis / chemically induced Seizures / drug therapy Treatment Outcome Triazines / contraindications* Valproic Acid / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Triazines; 84057-84-1/lamotrigine; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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