Document Detail


Life-threatening intracranial bleeding in a newborn with congenital cytomegalovirus infection: late-onset neonatal hemorrhagic disease.
MedLine Citation:
PMID:  21083361     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The authors present a case of a 36-day-old infant with intracranial and intramuscular hemorrhage due to vitamin K deficiency bleeding, who received intramuscular vitamin K prophylaxis at birth. In this case, laboratory tests showed anemia, liver dysfunction with cholestasis, and coagulopathy, consistent with vitamin K deficiency abnormality. Serological analyses showed that cytomegalovirus immunoglobulin (Ig)M and IgG avidity were both positive. The infant was treated successfully with intravenous ganciclovir and blood products. This case suggests that it is imperative to meticulously investigate the etiology in neonates with late-onset hemorrhagic disease of the newborn. Cholestatic liver disease caused by congenital cytomegalovirus infection should be in mind in term infants who presented with late-onset hemorrhagic disease.
Authors:
Yildiz Dallar; Ulku Tiras; Tulin Catakli; Gonul Gulal; Yavuz Sayar; Beray Selvar; Bulent Alioglu
Publication Detail:
Type:  Journal Article     Date:  2010-11-17
Journal Detail:
Title:  Pediatric hematology and oncology     Volume:  28     ISSN:  1521-0669     ISO Abbreviation:  Pediatr Hematol Oncol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8700164     Medline TA:  Pediatr Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  78-82     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Ankara Training and Research Hospital, The Ministry of Health of Turkey, Ankara, Turkey.
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