Document Detail

Life-threatening haematemesis associated with clozapine: a case report and literature review.
MedLine Citation:
PMID:  24167703     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Clozapine is regarded as a second-line and in some cases last-line antipsychotic known for its common life-threatening side effects, such as agranulocytosis, constipation and cardiomyopathies, but rarely haematemesis. We report a case of severe haemetemesis in a chronic schizophrenic patient managed with clozapine. The patient was a 46-year-old male being managed for chronic schizophrenia with treatment resistance who developed sudden severe haematemesis following commencement of clozapine for 6 weeks. The patient had 1.1 l of blood transfusion. The relevant literature is reviewed. Clozapine can be associated with a life-threatening haematemesis. Psychiatrists and other medical specialists need to be alert to the fatality of clozapine-induced haematemesis in the treatment of psychiatric disorders.
Kazeem Olaide Adebayo; Nurudeen Ibrahim; Temilola Mosanya; Benjamin Eegunranti; Babatunde Suleiman; Akeem Ayankunle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic advances in psychopharmacology     Volume:  3     ISSN:  2045-1253     ISO Abbreviation:  Ther Adv Psychopharmacol     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-29     Completed Date:  2013-10-29     Revised Date:  2013-11-01    
Medline Journal Info:
Nlm Unique ID:  101555693     Medline TA:  Ther Adv Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  275-7     Citation Subset:  -    
Department of Psychiatry, Ladoke Akintola University Teaching Hospital, Osogbo, Nigeria.
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