Document Detail

Life-threatening fish allergy successfully treated with immunotherapy.
MedLine Citation:
PMID:  9617781     Owner:  NLM     Status:  MEDLINE    
Manifestations of fish allergy can include near-fatal anaphylactic reaction. In very sensitive patients, fish odors and cooking vapors may have some allergenic activity. We reported a case of life-threatening fish allergy in a girl of 39 months referred for three episodes of Quincke edema with wheezing, cyanosis and severe urticaria after fish consumption or inhalation. Reagins were found against codfish and direct skin prick test with fresh food (codfish) showed important local reaction. Strict avoidance of fish in the diet is usually the only recommended procedure. However, in this particular case, the life-threatening nature of the allergic reaction was the major consideration to perform a desensitization. The child was treated by RUSH immunotherapy using codfish extracts from BENCARD company, following the schedule for insect venom allergy described by Pharmacia. Immunotherapy was performed immediately after determination of the threshold of sensitivity by specific skin prick tests and intra-dermal injections. Desensitization was initiated with a 1/10 dilution of the cut-off solution and 5 subcutaneous injections were administered daily. When important local reactions were observed, additional doses were necessary to obtain tolerance. After the RUSH therapy, the child was submitted to uncooked codfish odors without any reaction. No reaction has been observed even when the child has accidentally eaten a little piece of codfish.
G Casimir; P Cuvelier; S Allard; J Duchateau
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  8     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  1997 May 
Date Detail:
Created Date:  1998-07-31     Completed Date:  1998-07-31     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  103-5     Citation Subset:  IM    
Department of Pulmonology and Allergy, University Children's Hospital Queen Fabiola, Free University of Brussels (ULB), Belgium.
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MeSH Terms
Child, Preschool
Desensitization, Immunologic*
Fishes / immunology*
Food Hypersensitivity / therapy*
Histamine Release
Intradermal Tests
Skin Tests

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