| Life-threatening complications of hepatitis B virus-related polyarteritis nodosa developing despite interferon-alpha2b therapy: successful treatment with a combination of interferon, lamivudine, plasma exchanges and steroids. | |
| | |
MedLine Citation:
|
PMID: 11529642 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Polyarteritis nodosa (PAN) is a rare vasculitis associated with hepatitis B virus (HBV) infection in a significant proportion of cases. When used to treat HBV-related PAN, immunosuppressive agents may enhance viral replication and relaspes are frequent. In recent years the use of antiviral drugs has been proposed. We report the case of a patient with HBV-related PAN who, despite 6 weeks of interferon-alpha2b (IFN-alpha2b) monotherapy, developed life-threatening complications with bowel perforation. He was thereafter successfully treated with a combination of IFN-alpha2b, lamivudine, plasma exchanges and short-term steroids. In contrast to IFN-alpha2b, lamivudine is effective in rapidly suppressing viral replication. This may be valuable in the treatment of HBV-related PAN by contributing to a faster diminution of circulating immune complex levels. This case report highlights the importance of aggressive combined therapy in patients with HBV-related PAN. |
| | |
Authors:
|
P Deléaval; P Stadler; E Descombes; E Hecker; G Schrago; C Chizzolini; A Nicole; P Pugin; C Regamey |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Clinical rheumatology Volume: 20 ISSN: 0770-3198 ISO Abbreviation: Clin. Rheumatol. Publication Date: 2001 |
Date Detail:
|
Created Date: 2001-08-31 Completed Date: 2002-01-29 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: Belgium |
Other Details:
|
Languages: eng Pagination: 290-2 Citation Subset: IM |
Affiliation:
|
Hôpital Cantonal, Fribourg, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Combined Modality Therapy Critical Illness Disease Progression Drug Therapy, Combination Female Follow-Up Studies Hepatitis B / complications*, diagnosis, drug therapy Hepatitis B virus / drug effects, isolation & purification Humans Interferon Alfa-2b / administration & dosage* Lamivudine / administration & dosage* Plasma Exchange / methods* Polyarteritis Nodosa / diagnosis, therapy*, virology* Risk Assessment Steroids / administration & dosage* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Steroids; 134678-17-4/Lamivudine; 99210-65-8/Interferon Alfa-2b |
| Comments/Corrections | |
Comment In:
|
Clin Rheumatol. 2001;20(4):237-8
[PMID:
11529627
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chronic myeloid leukemia presenting as gout.
Next Document: Pulmonary haemorrhage in a 6-year-old boy with Henoch-Schönlein purpura.