Document Detail

Life-threatening angioedema in systemic lupus erythematosus.
MedLine Citation:
PMID:  11341109     Owner:  NLM     Status:  MEDLINE    
Life-threatening angioedema involving the upper respiratory tract is an uncommon manifestation in systemic lupus erythematosus (SLE). We report three patients in their late adolescence who had laryngeal oedema causing airway obstruction and requiring mechanical ventilation during active disease following symptoms of a respiratory tract infection. All of them had major organ involvement from lupus and none had a family history of hereditary angioedema (HAE). The mechanisms of angioedema in SLE are heterogeneous. There has been little evidence so far of anti-Cl inhibitor (Cl INH) autoantibody in SLE patients with angioedema. These are the first three cases reported in the literature of life-threatening angioedema following respiratory tract infection in SLE.
B Y Thong; J Thumboo; H S Howe; P H Feng
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Lupus     Volume:  10     ISSN:  0961-2033     ISO Abbreviation:  Lupus     Publication Date:  2001  
Date Detail:
Created Date:  2001-05-08     Completed Date:  2001-11-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  304-8     Citation Subset:  IM    
Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433.
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MeSH Terms
Airway Obstruction / etiology*,  physiopathology
Angioedema / etiology*,  physiopathology
Lupus Erythematosus, Systemic / complications*
Comment In:
Lupus. 2001;10(11):831-2   [PMID:  11789498 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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