Document Detail


Life support of artificial liver: development of a bioartificial liver to treat liver failure.
MedLine Citation:
PMID:  19110648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In recent years there has been a particular focus on research regarding tissue engineering targeting the liver, especially in terms of what types of cells and extracellular matrices should be organized and in what type of environments to create an artificial liver, i.e., a life-saving organ. The ideal is to use healthy human liver cells as a source of cells for such research, but there is an extreme shortage of human-donor livers that can be used for cell isolation. Therefore, we are presently working on the differentiation of embryonic stem cells into liver cells as well as reversibly immortalized human liver cell lines that can be cultured in large quantities and at low cost. We are also working on the development of a bioartificial liver (BAL) using such cells as a source. Herein, we introduce our findings on the current status of BAL development.
Authors:
Naoya Kobayashi
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-12-26
Journal Detail:
Title:  Journal of hepato-biliary-pancreatic surgery     Volume:  16     ISSN:  1436-0691     ISO Abbreviation:  J Hepatobiliary Pancreat Surg     Publication Date:  2009  
Date Detail:
Created Date:  2009-03-24     Completed Date:  2009-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431940     Medline TA:  J Hepatobiliary Pancreat Surg     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Affiliation:
Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. immortal@md.okayama-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Cell Transplantation / methods
Disease Models, Animal
Equipment Design
Graft Rejection
Graft Survival
Hepatocytes / transplantation
Humans
Liver Failure / surgery*
Liver, Artificial*
Tissue Engineering / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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