| Life style change and reverse cholesterol transport in obese women. | |
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MedLine Citation:
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PMID: 19857034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HDL cholesterol resp. apolipoprotein A1 concentrations are tools to estimate individual CVD risk, although only a part of HDL particles participate in reverse cholesterol transport (RCT). This discrepancy was analyzed in life style change based on increase of physical activity and dietary counseling. Efflux of cholesterol from pre-labeled macrophages to plasma acceptors of tested individuals was used as an RCT measure. Changes of lipoprotein parameters, glucose, fasting insulin concentrations and RCT were analyzed in 15 obese women after 9-week intervention consisted of 5 sessions of increased physical activity per week. Controlled increase in physical activity for 9 weeks induced a decrease of body weight averaging 9 kg (ranged from 2.3 to 15.5 kg). The intervention leads to significant decreases of triglycerides, apoprotein A1 and apoprotein B concentration, whereas total cholesterol, LDL cholesterol and HDL cholesterol did not change significantly. The increase of RCT was not significant, but there was highly significant negative correlation between individual decrease of body weight and an increase of RCT. Significant increase of RCT was found in 13 persons with a weight reduction more than 3.5 kg. Substantial weight loss is necessary to increase RCT. |
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Authors:
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I Kr??lov?? Lesn??; P Such??nek; J Kov??r; R Poledne |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 58 Suppl 1 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 2009 |
Date Detail:
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Created Date: 2009-10-27 Completed Date: 2010-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: S33-8 Citation Subset: IM |
Affiliation:
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Institute for Clinical and Experimental Medicine, Prague, Czech Republic. ivka@ikem.cz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apolipoprotein A-I / blood Apolipoproteins B / blood Biological Markers / blood Biological Transport Cholesterol / blood* Combined Modality Therapy Counseling* Diet* Exercise* Female Humans Macrophages / metabolism* Obesity / metabolism, physiopathology, therapy* Risk Reduction Behavior* Time Factors Treatment Outcome Triglycerides / blood Waist Circumference Weight Loss |
| Chemical | |
Reg. No./Substance:
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0/APOA1 protein, human; 0/Apolipoprotein A-I; 0/Apolipoproteins B; 0/Biological Markers; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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