Document Detail

Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging.
MedLine Citation:
PMID:  20848587     Owner:  NLM     Status:  MEDLINE    
Life expectancy at the turn of the 20th century was 46 years on average worldwide and it is around 65 years today. The correlative increase in age-associated diseases incidence has a profound public health impact and is an important matter of concern for our societies. Aging is a complex, heterogeneous, and multifactorial phenomenon, which is the consequence of multiple interactions between genes and environment. In this review, we survey animals models that have been of great help for both investigating mechanism of aging and identifying molecules, which slow down the onset of age-related diseases. Resveratrol (RSV) is one of those. We will report evidences supporting RSV as a molecule that acts by mimicking the beneficial effects of dietary restriction, and may share common downstream targets with rapamycin and metformin. Although those molecules do not reveal all the secrets of the fountain of youth, they may help us maintaining the quality of life in the old age.
Laurent Mouchiroud; Laurent Molin; Nicolas Dallière; Florence Solari
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  36     ISSN:  1872-8081     ISO Abbreviation:  Biofactors     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-02-11     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  377-82     Citation Subset:  IM    
Copyright Information:
© 2010 International Union of Biochemistry and Molecular Biology, Inc.
UMR, CNRS Université Lyon, Centre Léon Bérard, France.
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MeSH Terms
AMP-Activated Protein Kinases / physiology
Aging / drug effects
Energy Intake
Life Expectancy*
Longevity / drug effects*
Metformin / pharmacology*
Sirolimus / pharmacology*
Sirtuin 1 / physiology
Sirtuin 2 / physiology
Stilbenes / pharmacology*
Trans-Activators / physiology
Reg. No./Substance:
0/Ppargc1a protein, mouse; 0/Stilbenes; 0/Trans-Activators; 53123-88-9/Sirolimus; 657-24-9/Metformin; EC Protein Kinases; EC 3.5.1.-/Sirtuin 1; EC 3.5.1.-/Sirtuin 2; Q369O8926L/resveratrol

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