| Life history, immune function, and intestinal helminths: Trade-offs among immunoglobulin E, C-reactive protein, and growth in an Amazonian population. | |
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MedLine Citation:
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PMID: 20865759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Infection with helminths is associated with shifts in host immunity, including increased production of immunoglobulin E (IgE) and reduced inflammation. Given limited energy budgets, these shifts may involve changes in energy allocation toward competing demands. Here we test for potential trade-offs between growth, IgE, and the inflammatory marker C-reactive protein (CRP). METHODS: Dried blood spots and anthropometrics were collected from 162 Shuar forager-horticulturalists from a village in southeastern Ecuador. Enzyme-linked immunosorbent assays (ELISAs) were used to measure IgE and CRP. Relationships among IgE, CRP, and anthropometrics were examined in three groups: children aged 2-7 years (n = 63), children aged 8-15 (n = 61), and adults over age 18 (n = 37). RESULTS: Geometric mean IgE was 1,196 IU ml⁻¹ while geometric mean CRP was 1.33 mg l⁻¹. In children, IgE and CRP were negatively correlated (r = -0.21, P = 0.02, df = 122). Controlling for fat stores and age, IgE was associated with lower stature in children (t = -2.04, P = 0.04, df = 109), and adults (t = -3.29, P < 0.01, df = 33). In children there was a significant interaction between age and CRP, such that in younger children CRP was associated with shorter stature, but in older children was associated with greater stature (t = 2.15, P = 0.04, df = 109). CONCLUSIONS: These results suggest that infection with helminths may have hidden costs associated with immunological changes, and that these costs may ultimately affect growth and other life history parameters. |
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Authors:
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Aaron D Blackwell; J Josh Snodgrass; Felicia C Madimenos; Lawrence S Sugiyama |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: American journal of human biology : the official journal of the Human Biology Council Volume: 22 ISSN: 1520-6300 ISO Abbreviation: Am. J. Hum. Biol. Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2011-02-03 Revised Date: 2013-01-09 |
Medline Journal Info:
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Nlm Unique ID: 8915029 Medline TA: Am J Hum Biol Country: United States |
Other Details:
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Languages: eng Pagination: 836-48 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley-Liss, Inc. |
Affiliation:
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Integrative Anthropological Sciences, University of California, Santa Barbara, California 93106-3210, USA. ablackwell@isber.ucsb.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Body Weights and Measures C-Reactive Protein / analysis* Child Child, Preschool Ecuador / epidemiology Enzyme-Linked Immunosorbent Assay Female Growth / physiology* Health Surveys Helminthiasis / complications*, ethnology, immunology Humans Immunity Immunoglobulin E / blood* Indians, South American* Male |
| Grant Support | |
ID/Acronym/Agency:
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5DP1O000516-04/DP/NCCDPHP CDC HHS; DP1 OD000516/OD/NIH HHS; DP1 OD000516-04/OD/NIH HHS |
| Chemical | |
Reg. No./Substance:
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37341-29-0/Immunoglobulin E; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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