Document Detail


Life history, immune function, and intestinal helminths: Trade-offs among immunoglobulin E, C-reactive protein, and growth in an Amazonian population.
MedLine Citation:
PMID:  20865759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Infection with helminths is associated with shifts in host immunity, including increased production of immunoglobulin E (IgE) and reduced inflammation. Given limited energy budgets, these shifts may involve changes in energy allocation toward competing demands. Here we test for potential trade-offs between growth, IgE, and the inflammatory marker C-reactive protein (CRP).
METHODS: Dried blood spots and anthropometrics were collected from 162 Shuar forager-horticulturalists from a village in southeastern Ecuador. Enzyme-linked immunosorbent assays (ELISAs) were used to measure IgE and CRP. Relationships among IgE, CRP, and anthropometrics were examined in three groups: children aged 2-7 years (n = 63), children aged 8-15 (n = 61), and adults over age 18 (n = 37).
RESULTS: Geometric mean IgE was 1,196 IU ml⁻¹ while geometric mean CRP was 1.33 mg l⁻¹. In children, IgE and CRP were negatively correlated (r = -0.21, P = 0.02, df = 122). Controlling for fat stores and age, IgE was associated with lower stature in children (t = -2.04, P = 0.04, df = 109), and adults (t = -3.29, P < 0.01, df = 33). In children there was a significant interaction between age and CRP, such that in younger children CRP was associated with shorter stature, but in older children was associated with greater stature (t = 2.15, P = 0.04, df = 109).
CONCLUSIONS: These results suggest that infection with helminths may have hidden costs associated with immunological changes, and that these costs may ultimately affect growth and other life history parameters.
Authors:
Aaron D Blackwell; J Josh Snodgrass; Felicia C Madimenos; Lawrence S Sugiyama
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American journal of human biology : the official journal of the Human Biology Council     Volume:  22     ISSN:  1520-6300     ISO Abbreviation:  Am. J. Hum. Biol.     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-10-19     Completed Date:  2011-02-03     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  8915029     Medline TA:  Am J Hum Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  836-48     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley-Liss, Inc.
Affiliation:
Integrative Anthropological Sciences, University of California, Santa Barbara, California 93106-3210, USA. ablackwell@isber.ucsb.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Body Weights and Measures
C-Reactive Protein / analysis*
Child
Child, Preschool
Ecuador / epidemiology
Enzyme-Linked Immunosorbent Assay
Female
Growth / physiology*
Health Surveys
Helminthiasis / complications*,  ethnology,  immunology
Humans
Immunity
Immunoglobulin E / blood*
Indians, South American*
Male
Grant Support
ID/Acronym/Agency:
5DP1O000516-04/DP/NCCDPHP CDC HHS; DP1 OD000516/OD/NIH HHS; DP1 OD000516-04/OD/NIH HHS
Chemical
Reg. No./Substance:
37341-29-0/Immunoglobulin E; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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