Document Detail

Life-history connections to rates of aging in terrestrial vertebrates.
MedLine Citation:
PMID:  20479246     Owner:  NLM     Status:  MEDLINE    
The actuarial senescence (i.e., the rate of increase in adult mortality with age) was related to body mass, development period, and age at sexual maturity across 124 taxonomic families of terrestrial vertebrates. Model selection based on Akaike's information criterion values adjusted for small size showed that the rate of aging decreases with increasing body mass, gestation period, age at maturity, and possession of flight. Among families of mammals, actuarial senescence was related to extrinsic mortality rate (standardized regression coefficient = 0.215), gestation period (-0.217), and age at maturity (-0.553). Although rate of aging in birds also was related to the embryo development period, birds grow several times more rapidly than mammals, and therefore, the connection between rate of early development and rate of aging is unclear. The strong vertebrate-wide relationship between rate of aging, or life span, and age at maturity can be explained by density-dependent feedback of adult survival rate on the recruitment of young individuals into the breeding population. Thus, age at maturity seems to reflect extrinsic mortality, which, in turn, influences selection on mechanisms that postpone physiological and actuarial senescence. Because rate of embryo development influences rate of aging independently of the age at maturity, in a statistical sense, the evolutionary diversification of development and aging seem to be connected in both birds and mammals; however, the linking mechanisms are not known.
Robert E Ricklefs
Related Documents :
20426906 - Epidemiological analysis of primary liver cancer in the early 21st century in guangxi p...
11327166 - Bumpus in the snake den: effects of sex, size, and body condition on mortality of red-s...
17469266 - Optimum fishing strategies for isostichopusfuscus (echinodermata: holothuroidea) in the...
9778206 - Sex differences in mortality after myocardial infarction: evidence for a sex-age intera...
25117996 - Winter 25-hydroxyvitamin d levels in young urban adults are affected by smoking, body m...
7492866 - Comparison of areal and estimated volumetric bone mineral density values between older ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-05-17
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  107     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-06-29     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10314-9     Citation Subset:  IM    
Department of Biology, University of Missouri, St. Louis, MO 63121, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aging / genetics,  physiology*
Biological Evolution
Embryonic Development
Longevity / genetics,  physiology
Models, Biological
Sexual Maturation / genetics,  physiology
Vertebrates / classification,  genetics,  growth & development*,  physiology*
Grant Support
AG16895-01/AG/NIA NIH HHS; AG20263-01/AG/NIA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival an...
Next Document:  Marine biodiversity, ecosystem functioning, and carbon cycles.