| Life-extending dietary restriction and ovariectomy result in similar feeding rates but different physiological responses in grasshoppers. | |
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MedLine Citation:
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PMID: 21742024 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Dietary restriction (DR) and reduced reproduction each extend life span in many species. Females undergoing DR typically experience a reduction in their fecundity, which raises the question of whether the two treatments are actually extending life span in overlapping ways. Life span in lubber grasshoppers has been shown to be increased by DR, and separately by ovariectomy (OVX). Here, we test the combination of these on life span. If life extension by the two treatments are additive, it would suggest that they likely act through separate pathways. The experimental groups were: fully reproductive and fully fed (ShamFD); ovariectomized and fully fed (OVXFD); fully reproductive and restricted diet (ShamDR); and ovariectomized and restricted diet (OVXDR). The median life spans of these groups were: ShamFD=245d, OVXFD=285d, ShamDR=286d, and OVXDR=322d. Feeding rate for the OVXFD group was 64% of adlibitum, not significantly different from the 70% of adlibitum that was used for ShamDR. We also measured hemolymph parameters of physiology in these same individuals. Hemolymph levels of vitellogenin (the egg yolk-precursor protein) were increased 5-fold by OVX, but were not affected by DR. In addition, hemolymph total anti-oxidant activity (per μg protein) was significantly reduced by OVX, but was not affected by DR. We show that OVX and DR produce different physiological responses in grasshoppers, despite life extensions and feeding levels that were not significantly different. These data suggest that OVX and DR might extend life span via distinct pathways. |
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Authors:
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M D Drewry; J M Williams; J D Hatle |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-1 |
Journal Detail:
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Title: Experimental gerontology Volume: - ISSN: 1873-6815 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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