| Life on the edge: the balance between macrofauna, microflora and host immunity. | |
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MedLine Citation:
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PMID: 22257556 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Mammals, microflora and gut-dwelling macrofauna have co-evolved over many millions of years until relatively recently when the geographical prevalence of macrofauna in humans has become restricted to the developing world. Immune homeostasis relies on a balance in the composition of intestinal microflora; long-lived macrofauna have also been shown to regulate immune function, and their absence in Western lifestyles is suggested to be a factor for the increasing frequency of allergy and autoimmunity. The intestinal nematode Trichuris muris was recently demonstrated to utilise microflora to initiate its life cycle. The interdependence on one another of all three factors is such that when the balance is perturbed it must be realigned or the consequences may be detrimental to the mammalian host. |
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Authors:
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Allison J Bancroft; Kelly S Hayes; Richard K Grencis |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-16 |
Journal Detail:
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Title: Trends in parasitology Volume: - ISSN: 1471-5007 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966034 Medline TA: Trends Parasitol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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Manchester Immunology Group, Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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