Document Detail

Life and death of female gametes during oogenesis and folliculogenesis.
MedLine Citation:
PMID:  18622770     Owner:  NLM     Status:  MEDLINE    
The vertebrate ovary is an extremely dynamic organ in which excessive or defective follicles are rapidly and effectively eliminated early in ontogeny and thereafter continuously throughout reproductive life. More than 99% of follicles disappear, primarily due to apoptosis of granulosa cells, and only a minute fraction of the surviving follicles successfully complete the path to ovulation. The balance between signals for cell death and survival determines the destiny of the follicles. An abnormally high rate of cell death followed by atresia can negatively affect fertility and eventually lead irreversibly to premature ovarian failure. In this review we provide a short overview of the role of programmed cell death in prenatal differentiation of the primordial germ cells and in postnatal folliculogenesis. We also discuss the issue of neo-oogenesis. Next, we highlight molecules involved in regulation of granulosa cell apoptosis. We further discuss the potential use of scores for apoptosis in granulosa cells and characteristics of follicular fluid as prognostic markers for predicting the outcome of assisted reproduction. Potential therapeutic strategies for combating premature ovarian failure are also addressed.
Dmitri V Krysko; Araceli Diez-Fraile; Godelieve Criel; Andrei A Svistunov; Peter Vandenabeele; Katharina D'Herde
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-07-14
Journal Detail:
Title:  Apoptosis : an international journal on programmed cell death     Volume:  13     ISSN:  1573-675X     ISO Abbreviation:  Apoptosis     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2008-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712129     Medline TA:  Apoptosis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1065-87     Citation Subset:  IM    
Department for Molecular Biomedical Research, Molecular Signaling and Cell Death Unit, VIB, Technologiepark 927, 9052 Ghent, (Zwijnaarde), Belgium.
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MeSH Terms
Cell Death
Ovarian Follicle / cytology*,  growth & development*
Ovum / cytology*
Reproductive Techniques, Assisted

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