Document Detail

Life course path analysis of birth weight, childhood growth, and adult systolic blood pressure.
MedLine Citation:
PMID:  19357327     Owner:  NLM     Status:  MEDLINE    
The inverse associations between birth weight and later adverse health outcomes and the positive associations between adult body size and poor health imply that increases in relative body size between birth and adulthood may be undesirable. In this paper, the authors describe life course path analysis, a method that can be used to jointly estimate associations between body sizes at different time points and associations of body sizes throughout life with health outcomes. Additionally, this method makes it possible to assess both the direct effect and the indirect effect mediated through later body size, and thereby the total effect, of size and changes in size on later outcomes. Using data on childhood body size and adult systolic blood pressure from a sample of 1,284 Danish men born between 1936 and 1970, the authors compared results from path analysis with results from 3 standard regression methods. Path analysis produced easily interpretable results, and compared with standard regression methods it produced a noteworthy gain in statistical power. The effect of change in relative body size on adult blood pressure was more pronounced after age 11 years than in earlier childhood. These results suggest that increases in body size prior to age 11 years are less harmful to adult blood pressure than increases occurring after this age.
Michael Gamborg; Per Kragh Andersen; Jennifer L Baker; Esben Budtz-Jørgensen; Torben Jørgensen; Gorm Jensen; Thorkild I A Sørensen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-04-08
Journal Detail:
Title:  American journal of epidemiology     Volume:  169     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-01     Completed Date:  2009-06-08     Revised Date:  2010-09-24    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1167-78     Citation Subset:  IM    
Institute of Preventive Medicine, Copenhagen University Hospital and Center for Health and Society, University of Copenhagen, Copenhagen K, Denmark.
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MeSH Terms
Adolescent Development / physiology*
Birth Weight*
Blood Pressure*
Body Mass Index*
Child Development / physiology*
Epidemiologic Methods
Models, Statistical
Regression Analysis
Grant Support
Comment In:
Am J Epidemiol. 2009 May 15;169(10):1179-81   [PMID:  19357325 ]

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