Document Detail

Lidocaine+clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects.
MedLine Citation:
PMID:  17822879     Owner:  NLM     Status:  MEDLINE    
The local anaesthetic and haemodynamic parameters achieved by lidocaine with clonidine or epinephrine, administered for maxillary infiltration anaesthesia, were studied in 40 patients (American Society of Anesthesiologists, physical status 1) who underwent upper third molar surgery. All patients received 2 ml of 2% lidocaine with clonidine (15 microg/ml; n=20) or epinephrine (12.5 microg/ml; n=20) in a randomized, double-blind fashion. Vascular effects were evaluated on the isolated human infraorbital arteries. The parameters of maxillary infiltration anaesthsia produced by a combination of lidocaine+clonidine were similar to those obtained with lidocaine+epinephrine. In both groups, haemodynamic parameters exhibited similar variations, with the exception of a significant reduction in heart rate and systolic blood pressure in the lidocaine+clonidine group and significant increase in heart rate in the lidocaine+epinephrine group, 10 min after surgery. Clonidine (10(-7), 10(-6) and 10(-5)M) produced an endothelium-independent vasocontractile effect on the isolated human infraorbital arteries. The results of this study indicate for the first time in dental anaesthesia that the lidocaine+clonidine combination could be a useful and safe alternative to lidocaine+epinephrine for intraoral infiltration anaesthesia.
B Brkovic; M Gardasevic; J Roganovic; N Jovic; L Todorovic; D Stojic
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2007-09-06
Journal Detail:
Title:  International journal of oral and maxillofacial surgery     Volume:  37     ISSN:  0901-5027     ISO Abbreviation:  Int J Oral Maxillofac Surg     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-12     Completed Date:  2008-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605826     Medline TA:  Int J Oral Maxillofac Surg     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  149-55     Citation Subset:  D; IM    
Clinic of Oral Surgery, Dental School, University of Belgrade, Serbia.
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MeSH Terms
Adrenergic alpha-Agonists / therapeutic use
Analgesics / therapeutic use
Anesthesia, Local / methods*
Anesthetics, Local / administration & dosage*
Arteries / drug effects
Blood Pressure / drug effects
Clonidine / administration & dosage,  therapeutic use*
Double-Blind Method
Epinephrine / administration & dosage,  therapeutic use
Heart Rate / drug effects
Hemodynamics / drug effects
Lidocaine / administration & dosage*
Maxilla / drug effects
Molar, Third / surgery
Orbit / blood supply
Pain Threshold / drug effects
Pain, Postoperative / drug therapy,  etiology
Sensation / drug effects
Time Factors
Tissue Culture Techniques
Tooth Extraction*
Tooth, Impacted / surgery
Vasoconstrictor Agents / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Analgesics; 0/Anesthetics, Local; 0/Vasoconstrictor Agents; 137-58-6/Lidocaine; 4205-90-7/Clonidine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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