| Lidocaine+clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects. | |
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MedLine Citation:
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PMID: 17822879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The local anaesthetic and haemodynamic parameters achieved by lidocaine with clonidine or epinephrine, administered for maxillary infiltration anaesthesia, were studied in 40 patients (American Society of Anesthesiologists, physical status 1) who underwent upper third molar surgery. All patients received 2 ml of 2% lidocaine with clonidine (15 microg/ml; n=20) or epinephrine (12.5 microg/ml; n=20) in a randomized, double-blind fashion. Vascular effects were evaluated on the isolated human infraorbital arteries. The parameters of maxillary infiltration anaesthsia produced by a combination of lidocaine+clonidine were similar to those obtained with lidocaine+epinephrine. In both groups, haemodynamic parameters exhibited similar variations, with the exception of a significant reduction in heart rate and systolic blood pressure in the lidocaine+clonidine group and significant increase in heart rate in the lidocaine+epinephrine group, 10 min after surgery. Clonidine (10(-7), 10(-6) and 10(-5)M) produced an endothelium-independent vasocontractile effect on the isolated human infraorbital arteries. The results of this study indicate for the first time in dental anaesthesia that the lidocaine+clonidine combination could be a useful and safe alternative to lidocaine+epinephrine for intraoral infiltration anaesthesia. |
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Authors:
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B Brkovic; M Gardasevic; J Roganovic; N Jovic; L Todorovic; D Stojic |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2007-09-06 |
Journal Detail:
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Title: International journal of oral and maxillofacial surgery Volume: 37 ISSN: 0901-5027 ISO Abbreviation: Int J Oral Maxillofac Surg Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-12 Completed Date: 2008-05-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8605826 Medline TA: Int J Oral Maxillofac Surg Country: Denmark |
Other Details:
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Languages: eng Pagination: 149-55 Citation Subset: D; IM |
Affiliation:
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Clinic of Oral Surgery, Dental School, University of Belgrade, Serbia. brkovic73@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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therapeutic use Adult Analgesics / therapeutic use Anesthesia, Local / methods* Anesthetics, Local / administration & dosage* Arteries / drug effects Blood Pressure / drug effects Clonidine / administration & dosage, therapeutic use* Double-Blind Method Epinephrine / administration & dosage, therapeutic use Female Heart Rate / drug effects Hemodynamics / drug effects Humans Lidocaine / administration & dosage* Male Maxilla / drug effects Molar, Third / surgery Orbit / blood supply Pain Threshold / drug effects Pain, Postoperative / drug therapy, etiology Sensation / drug effects Time Factors Tissue Culture Techniques Tooth Extraction* Tooth, Impacted / surgery Vasoconstrictor Agents / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Analgesics; 0/Anesthetics, Local; 0/Vasoconstrictor Agents; 137-58-6/Lidocaine; 4205-90-7/Clonidine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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