| Lidocaine and surgical modification reduces mortality in a rat model of cardiac failure induced by coronary artery ligation. | |
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MedLine Citation:
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PMID: 11257484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary artery ligation in the rat provides a useful experimental model of cardiac failure; however, this procedure carries with it a high mortality rate (50%). In this study, we used lidocaine (10 mg/kg, i.m.) before coronary artery ligation and 2 h after surgery to minimise the incidence of ventricular fibrillation (VF) that leads to sudden death in this model. We found that coronary artery ligation, using lidocaine in conjunction with a modified surgical procedure, had a mortality rate of 15%, much lower than reported in previous studies using this model. These modifications allow for the production of larger infarcts with 29% of animals having an infarct size > 50% of the epicardial surface. Infarct size in our myocardial infarction (MI) group varied between 5% and 75% of the left ventricular (LV) surface area resulting in a mean infarct size of 41.3 +/- 1.3% for the epicardial surface and 40.0 +/- 1.3% for the endocardial surface. |
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Authors:
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A R Kompa; R J Summers |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pharmacological and toxicological methods Volume: 43 ISSN: 1056-8719 ISO Abbreviation: J Pharmacol Toxicol Methods Publication Date: 2000 May-Jun |
Date Detail:
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Created Date: 2001-03-21 Completed Date: 2001-05-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9206091 Medline TA: J Pharmacol Toxicol Methods Country: United States |
Other Details:
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Languages: eng Pagination: 199-203 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Monash University, Victoria 3800, Australia. andrew.kompa@med.monash.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Arrhythmia Agents / therapeutic use* Body Weight Coronary Vessels / physiology* Heart Failure / drug therapy, surgery, therapy* Lidocaine / therapeutic use* Ligation Male Myocardial Infarction / pathology Myocardium / pathology Organ Size Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 137-58-6/Lidocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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