Document Detail

Lidocaine and surgical modification reduces mortality in a rat model of cardiac failure induced by coronary artery ligation.
MedLine Citation:
PMID:  11257484     Owner:  NLM     Status:  MEDLINE    
Coronary artery ligation in the rat provides a useful experimental model of cardiac failure; however, this procedure carries with it a high mortality rate (50%). In this study, we used lidocaine (10 mg/kg, i.m.) before coronary artery ligation and 2 h after surgery to minimise the incidence of ventricular fibrillation (VF) that leads to sudden death in this model. We found that coronary artery ligation, using lidocaine in conjunction with a modified surgical procedure, had a mortality rate of 15%, much lower than reported in previous studies using this model. These modifications allow for the production of larger infarcts with 29% of animals having an infarct size > 50% of the epicardial surface. Infarct size in our myocardial infarction (MI) group varied between 5% and 75% of the left ventricular (LV) surface area resulting in a mean infarct size of 41.3 +/- 1.3% for the epicardial surface and 40.0 +/- 1.3% for the endocardial surface.
A R Kompa; R J Summers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmacological and toxicological methods     Volume:  43     ISSN:  1056-8719     ISO Abbreviation:  J Pharmacol Toxicol Methods     Publication Date:    2000 May-Jun
Date Detail:
Created Date:  2001-03-21     Completed Date:  2001-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9206091     Medline TA:  J Pharmacol Toxicol Methods     Country:  United States    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  IM    
Department of Pharmacology, Monash University, Victoria 3800, Australia.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use*
Body Weight
Coronary Vessels / physiology*
Heart Failure / drug therapy,  surgery,  therapy*
Lidocaine / therapeutic use*
Myocardial Infarction / pathology
Myocardium / pathology
Organ Size
Rats, Sprague-Dawley
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 137-58-6/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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