Document Detail

Lidocaine removal during resin hemoperfusion for phenobarbital intoxication.
MedLine Citation:
PMID:  6732553     Owner:  NLM     Status:  MEDLINE    
A deeply comatose patient with severe phenobarbital intoxication was hemoperfused with an Amerlite XAD-4 column. She was receiving lidocaine for ventricular ectopy. The rate of lidocaine infusion had to be increased to control ventricular arrhythmias during hemoperfusion. Plasma clearance for lidocaine by the column was 122 ml/min at initiation and 75 ml/min at 2 h. These findings suggest that an increment in lidocaine infusion may be needed during resin hemoperfusion in patients receiving this drug because of its removal by the column.
K Barber; S M Chen; R Ferguson; M S Kramer; R M Raja
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial organs     Volume:  8     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-07-20     Completed Date:  1984-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-31     Citation Subset:  IM    
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MeSH Terms
Ion Exchange Resins
Lidocaine / blood*,  therapeutic use
Middle Aged
Phenobarbital / blood,  poisoning*
Reg. No./Substance:
0/Ion Exchange Resins; 0/Polystyrenes; 0/Polyvinyls; 137-58-6/Lidocaine; 37380-42-0/XAD-4 resin; 50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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