| Lidocaine reduces ischaemic but not reperfusion injury in isolated rat heart. | |
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MedLine Citation:
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PMID: 11573594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The local anaesthetic lidocaine protects the myocardium in ischaemia-reperfusion situations. It is not known if this is the consequence of an anti-ischaemic effect or an effect on reperfusion injury. Therefore, we investigated the effect of two concentrations of lidocaine on myocardial ischaemia-reperfusion injury and on reperfusion injury alone. We used an isolated rat heart model where heart rate, ventricular volume and coronary flow were kept constant. Hearts underwent 45 min of low-flow ischaemia followed by 90 min reperfusion. Two groups received lidocaine 1.7 or 17 microg ml(-1) starting 5 min before the onset of reperfusion. In two additional groups, lidocaine infusion started 5 min before low-flow ischaemia. In all groups, lidocaine administration was stopped after 15 min of reperfusion. One group served as an untreated control (n=11 in each group). Left ventricular developed pressure (LVDP) and total creatine kinase release (CKR) were measured. Lidocaine administration during ischaemia and reperfusion led to an improved recovery of LVDP during reperfusion (1.7 microg ml(-1), 54 (SEM 10) mm Hg; 17 microg ml(-1), 71 (9) mm Hg at 30 min of reperfusion; both significantly different from control (21 (4) mm Hg) (P<0.05)) and a reduced CKR (1.7 microg ml(-1), 79 (13) IU; 17 microg ml(-1), 52 (8) IU at 30 min of reperfusion; both significantly different from control (130 (8) IU (P<0.05)). Lidocaine given during early reperfusion only, affected neither LVDP during reperfusion (1.7 microg ml(-1), 19 (6) mm Hg (P=1.0); 17 microg ml(-1), 36 (8) mm Hg (P=0.46)) nor CKR (156 (21) IU (P=0.50) and 106 (14) IU (P=0.57)). We conclude that lidocaine protects the myocardium against ischaemic but not against reperfusion injury in the isolated rat heart. |
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Authors:
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D Ebel; P Lipfert; J Frässdorf; B Preckel; J Müllenheim; V Thämer; W Schlack |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of anaesthesia Volume: 86 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-09-27 Completed Date: 2001-10-11 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 846-52 Citation Subset: IM |
Affiliation:
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Physiologisches Institut I, Abteilung für Herz- und Kreislaufphysiologie, Heinrich-Heine-Universität Düsseldorf, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Anesthetics, Local / administration & dosage* Animals Creatine Kinase / metabolism Lidocaine / administration & dosage* Male Metabolic Clearance Rate / drug effects Myocardial Ischemia / metabolism, physiopathology, prevention & control* Myocardial Reperfusion Injury / metabolism, physiopathology, prevention & control Myocardium / metabolism Oxygen Consumption Perfusion Rats Rats, Wistar Ventricular Pressure / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 137-58-6/Lidocaine; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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