Document Detail

Lidocaine-prilocaine (EMLA) cream as analgesia for hysterosalpingography: a prospective, randomized, controlled, double blinded study.
MedLine Citation:
PMID:  17234675     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of our study is to evaluate the efficacy of applying lidocaine 25 mg-prilocaine-25 mg/G cream (EMLA 5%) on the uterine cervix for pain relief when performing hysterosalpingography (HSG). METHODS: Eighty-two patients undergoing HSG as part of infertility evaluation were randomized into groups receiving EMLA (42) or placebo cream (40) in a double-blinded prospective study from which four women were later excluded. The cream was applied to the uterine cervix by means of a cervical cup 30 min before the HSG. Pain perception related to the HSG procedure was scored by visual analogue scale (VAS) at five predefined steps: after speculum application, after cervical instrumentation of the tenaculum and cannula, at the end of uterine filling, at completion of tubal spillage, and immediately following instrument removal. In addition, the patients were asked to retrospectively rate the pain during the entire procedure in a telephone interview the following day. RESULTS: Cervical instrumentation was found to be the most painful step of HSG (P < 0.001). When comparing the VAS pain scores, cervical instrumentation in the EMLA-treated patients was associated with significantly less pain than the control group: 3.3 +/- 2.9 versus 4.9 +/- 2.7, respectively (P = 0.02). CONCLUSIONS: Topical application of EMLA 5% cream on the uterine cervix before performing HSG significantly reduced the pain during this procedure.
G Liberty; M Gal; T Halevy-Shalem; R Michaelson-Cohen; N Galoyan; J Hyman; T Eldar-Geva; E Vatashsky; E Margalioth
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2007-01-18
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  22     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-19     Completed Date:  2007-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1335-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem.
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MeSH Terms
Administration, Topical
Analgesia / methods*
Cervix Uteri / drug effects
Double-Blind Method
Hysterosalpingography / methods*
Pain Measurement
Reg. No./Substance:
0/EMLA; 137-58-6/Lidocaine; 721-50-6/Prilocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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