Document Detail

Lidocaine for prevention of reperfusion ventricular fibrillation after release of aortic cross-clamping.
MedLine Citation:
PMID:  11052433     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the efficacy of a bolus of lidocaine administered by way of the pump before releasing the aortic cross-clamp (ACC) in preventing the occurrence of reperfusion ventricular fibrillation. DESIGN: Prospective, randomized study. SETTING: University hospital. PARTICIPANTS: Patients undergoing coronary artery bypass graft surgery (n = 34). INTERVENTIONS: Seventeen patients received 100 mg of lidocaine by way of the pump 2 minutes before releasing the ACC, and a control group of 17 patients received 5 mL of normal saline. MEASUREMENTS AND MAIN RESULTS: In the control group, the incidence of reperfusion ventricular fibrillation was 70%, which was significantly decreased to 11% in the lidocaine group. A higher cardiac output after weaning from cardiopulmonary bypass was observed in the lidocaine group; this may be attributed to the lower incidence of reperfusion ventricular fibrillation and consequently the lower need for defibrillation by electric countershocks. CONCLUSIONS: The results suggest that a bolus of 100 mg of lidocaine administered 2 minutes before release of the ACC can safely decrease the incidence of reperfusion ventricular fibrillation and is associated with better hemodynamics after weaning from cardiopulmonary bypass.
A Baraka; N Kawkabani; A Dabbous; M Nawfal
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  14     ISSN:  1053-0770     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-02-07     Completed Date:  2001-02-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  531-3     Citation Subset:  IM    
Department of Anesthesiology, American University of Beirut, Lebanon.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use*
Coronary Artery Bypass / adverse effects*
Hemodynamics / drug effects
Lidocaine / therapeutic use*
Middle Aged
Myocardial Reperfusion Injury / prevention & control*
Prospective Studies
Ventricular Fibrillation / prevention & control*
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 137-58-6/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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