| Lidocaine for prevention of reperfusion ventricular fibrillation after release of aortic cross-clamping. | |
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MedLine Citation:
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PMID: 11052433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the efficacy of a bolus of lidocaine administered by way of the pump before releasing the aortic cross-clamp (ACC) in preventing the occurrence of reperfusion ventricular fibrillation. DESIGN: Prospective, randomized study. SETTING: University hospital. PARTICIPANTS: Patients undergoing coronary artery bypass graft surgery (n = 34). INTERVENTIONS: Seventeen patients received 100 mg of lidocaine by way of the pump 2 minutes before releasing the ACC, and a control group of 17 patients received 5 mL of normal saline. MEASUREMENTS AND MAIN RESULTS: In the control group, the incidence of reperfusion ventricular fibrillation was 70%, which was significantly decreased to 11% in the lidocaine group. A higher cardiac output after weaning from cardiopulmonary bypass was observed in the lidocaine group; this may be attributed to the lower incidence of reperfusion ventricular fibrillation and consequently the lower need for defibrillation by electric countershocks. CONCLUSIONS: The results suggest that a bolus of 100 mg of lidocaine administered 2 minutes before release of the ACC can safely decrease the incidence of reperfusion ventricular fibrillation and is associated with better hemodynamics after weaning from cardiopulmonary bypass. |
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Authors:
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A Baraka; N Kawkabani; A Dabbous; M Nawfal |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of cardiothoracic and vascular anesthesia Volume: 14 ISSN: 1053-0770 ISO Abbreviation: J. Cardiothorac. Vasc. Anesth. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2001-02-07 Completed Date: 2001-02-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9110208 Medline TA: J Cardiothorac Vasc Anesth Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 531-3 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, American University of Beirut, Lebanon. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-Arrhythmia Agents / therapeutic use* Coronary Artery Bypass / adverse effects* Female Hemodynamics / drug effects Humans Lidocaine / therapeutic use* Male Middle Aged Myocardial Reperfusion Injury / prevention & control* Prospective Studies Ventricular Fibrillation / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 137-58-6/Lidocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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