| Liddle's syndrome, an uncommon form of hyporeninemic hypoaldosteronism: functional and histopathological studies. | |
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MedLine Citation:
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PMID: 3550146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Liddle's syndrome was diagnosed in a 72-year-old man who presented clinically with hypertension and muscle weakness. This disorder has been characterized by hyporeninemic hypoaldosteronism, hypertension, hypokalemia and enhanced erythrocyte sodium influx. Administration of spironolactone failed to correct the hypertension and electrolyte abnormality, which subsequently improved with triamterene therapy and a low salt diet. However, suppression of the renin-angiotensin-aldosterone system remained unchanged after this treatment. In addition, an atrophic juxtaglomerular apparatus and hypertensive lesions in the arterioles were confirmed by kidney biopsy after triamterene therapy. Therefore, a process of intrinsic hyperactive distal sodium reabsorption, probably affected by aldosterone-independent sodium transport into erythrocytes, appears to be important in the pathogenesis of this syndrome. Triamterene therapy, which usually is performed in patients with this disease, might not be the ultimate therapy in the future even if electrolyte abnormalities were to be improved temporarily. |
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Authors:
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T Nakada; H Koike; T Akiya; T Katayama; S Kawamata; K Takaya; H Shigematsu |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of urology Volume: 137 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1987-04-27 Completed Date: 1987-04-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 636-40 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aldosterone / deficiency* Humans Kidney / pathology*, physiopathology Male Renin / blood* Spironolactone / diagnostic use Syndrome Triamterene / diagnostic use |
| Chemical | |
Reg. No./Substance:
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396-01-0/Triamterene; 52-01-7/Spironolactone; 52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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