| Liddle syndrome in a newborn infant. | |
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MedLine Citation:
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PMID: 12185466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 10-week-old female infant developed hypertension. The elevated blood pressure was associated with metabolic alkalosis and urinary chloride wastage. The family history was unremarkable. Her urinalysis, blood urea nitrogen (BUN), and serum creatinine concentrations were all normal. A renal ultrasound was normal. A technetium-99m diethylenetriaminopentoacetic acid (DTPA) renal scan with captopril showed normal blood flow bilaterally. The head ultrasound and echocardiogram were normal. Blood epinephrine, norepinephrine, catecholamines, thyroxine, and steroid levels were also normal. Treatment with various combinations of labetalol, hydralazine, captopril, methyldopa, nifedipine, and spironolactone, all at high doses, failed to control the elevated blood pressure. Serum aldosterone level and peripheral plasma renin activity were low. The lack of therapeutic response to spironolactone, with a good response to amiloride and recurrence of hypertension and metabolic alkalosis after amiloride cessation that was subsequently treated with amiloride, established the diagnosis of Liddle syndrome. To our knowledge, this is the youngest patient with Liddle syndrome that has been reported in the literature. |
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Authors:
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Farahnak K Assadi; Robert E Kimura; Uma Subramanian; Sameer Patel |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2002-05-17 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 17 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-19 Completed Date: 2003-01-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 609-11 Citation Subset: IM |
Affiliation:
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Section of Nephrology, Rush Children's Hospital, Rush University Medical College, 1725 West Harrison Street, Suite 718, Chicago, IL 60612, USA. fassadi@rush.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkalosis
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drug therapy,
pathology* Amiloride / therapeutic use Blood Pressure / physiology Diuretics / therapeutic use Electrolytes / metabolism Failure to Thrive / drug therapy, pathology* Female Humans Hypertension / drug therapy, pathology* Hypokalemia / drug therapy, pathology* Infant, Newborn Kidney Diseases / drug therapy, pathology*, ultrasonography Kidney Function Tests Radiopharmaceuticals / therapeutic use Spironolactone / therapeutic use Syndrome Technetium Tc 99m Pentetate / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Diuretics; 0/Electrolytes; 0/Radiopharmaceuticals; 2609-46-3/Amiloride; 52-01-7/Spironolactone; 65454-61-7/Technetium Tc 99m Pentetate |
| Comments/Corrections | |
Comment In:
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Pediatr Nephrol. 2003 Jun;18(6):607-8; author reply 609
[PMID:
12759812
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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